1,2-二氯乙烷中毒糖皮质激素治疗后骨量减少与血脂、血钙相关性研究  

Correlational study of the relationship among serum lipid,calcium,and osteopenia in patients after the treatment of 1,2-dichloroethane poisoning with glucocorticoids

作　　者：刘旭良[1] 李斯明 郑介柏[1] 刘薇薇[1] 王兵[1] 刘贻运[1] 张程[1] 

机构地区：[1]广州医学院附属第十二人民医院,广州510620 [2]广州市红会医院

出　　处：《中国骨质疏松杂志》2013年第4期349-351,406,共4页Chinese Journal of Osteoporosis

摘　　要：目的评估职业性急性1,2-二氯乙烷中毒患者应用糖皮质激素所致骨量减少与血脂、血钙的相关性。方法选取某院2009年～2012年期间应用糖皮质激素治疗的职业性急性1,2-二氯乙烷中毒患者38例,采用双能X线骨密度仪测定相关部位的骨密度,记录低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、总胆固醇(CHOL)、甘油三酯(TRIG)、血清总钙(TCa)等临床资料,资料录入和统计采用SPSS统计软件包。结果 LDL-C、CHOL、TCa对骨量存在影响(P<0.05),而HDL-C、TRIG则对骨量无影响(P>0.05)。结论职业性急性1,2-二氯乙烷中毒患者应用糖皮质激素,可引起骨量减少或骨质疏松,严格控制血脂可能有助于减少骨量丢失。Objective To evaluate the relationship among serum lipid, calcium, and osteopenia in patients after the treatment of occupational acute 1,2-dichloroethane poisoning with glueocorticoids. Methods A total of 38 patients, who had occupational acute 1,2-dichloroethanc poisoning and received glucocorticoid treatment in our hospital from 2009 to 2012, were enrolled. Bone mineral density was detected using dual- energy X-ray absorptiometry. Clinical parameters including low density lipoprotein eholesterin （LDL-C）, high density lipoprotein cholesterol （HDL-C）, total cholesterol （CHOL）, triglyceride （TRIG）, and serum total calcium （TCa） were recorded. A SPSS 16.0 software was used for statistical analysis. Results The concentrations of LDL-C, CHOL, and TCa were correlated with osteopenia （P 〈 0. 05） , whereas the concentrations of both HDL-C and TRIG showed no correlation with ostcopenia （P 〉 0.05）. Conclusion The usage of glucocorticoids in patients with occupational acute 1,2-dichloroethane poisoning can cause osteopenia or osteoporosis. Strict control of serum lipid level may help preventing the loss of bone mass.

关 键 词：1 2-二氯乙烷中毒 骨量 血脂 血钙 

分 类 号：R322.71[医药卫生—人体解剖和组织胚胎学] R969.3[医药卫生—基础医学]