心脏与代谢  

Heart and metabolism

作　　者：杨士伟[1] 周玉杰[1] 许玉韵[2] 胡大一[3] 

机构地区：[1]首都医科大学附属北京安贞医院心内科、北京市心肺血管疾病研究所、教育部心血管重构相关疾病重点实验室,北京100029 [2]北京大学第一医院心内科,北京100034 [3]北京大学人民医院心内科,北京100044

出　　处：《中华老年多器官疾病杂志》2013年第4期241-243,共3页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：国家自然科学基金（No.81100143）;北京市教委重点项目（KZ201110025031）;首都『临床特色应用研究重点项目（Z0005190042811）;北京市科技新星项目（Z121107002512053）

摘　　要：相比于巨大的能量消耗，心脏的能量储备却很少，因此心脏对能量缺乏的耐受能力很低。心肌能量代谢受代谢底物浓度、激素水平、冠状动脉血流或组织营养状况等多种因素调节。血糖异常、甲状腺功能亢进或减低、高尿酸血症等均可影响心脏能量代谢的病理生理过程。尽管以往认为高血糖是冠心病患者生存率的独立预测因子，但强化降糖并未取得一致的效果，而新近的数项临床试验反而显示强化降糖可能增加心血管死亡率。心脏与代谢日趋发展成为一门新兴的学科，本期聚焦“心脏与代谢”，希望能够起到抛砖引玉的作用。Although the human heart is metabolically one of the most active organs in the body, the heart has a relatively low ATP content. Accordingly, the heart has low tolerance for energy deficiency. The regulation of myocardial metabolism is linked to multiple factors, including substrates concentration, hormone concentrations, coronary blood flow and nutritional status of the tissue, etc. Dysglycemia, hyper/hypo-thyroidism and hyperuricemia are all involved in the pathophysiological process of heart energy metabolism. Although hyperglycemia on admission is a powerful independent predictor of survival in patients with coronary heart disease, intervention to normalize glycemia has yielded inconsistent results. Indeed, recent large randomized controlled trials have failed to show a significant decrease in mortality with intensive glycemic control, or have even shown an increased mortality risk. ＂Heart and metabolism＂ is a rising discipline. We choose ＂Heart and Metabolism＂ as the topic of the special columm in this issue and want to have it account for a modest spur to induce others to come forward with valuable contributions.

关 键 词：心脏 能量 代谢 

分 类 号：R592[医药卫生—老年医学] R541[医药卫生—内科学]