生长因子在创伤愈合中作用的研究  

Review on the role of growth factor in wound healing

作　　者：王佳琪[1] 王国栋[1] 颜红柱[1] 吴洋[1] 

机构地区：[1]第二军医大学附属长征医院口腔科,上海200003

出　　处：《创伤外科杂志》2013年第3期281-283,F0003,共4页Journal of Traumatic Surgery

摘　　要：创伤愈合是一个复杂的生物学过程,包括出血与凝血、炎症渗出、血管和肉芽组织的形成、再上皮化、纤维化和瘢痕改建过程等,在这一系列的生物学过程中各种生长因子发挥着重要的作用;急性创伤时,生长因子能够发挥正常功能参与愈合过程,最后使皮肤屏障功能得到重建,而在慢性伤口中炎症细胞持续浸润导致伤口部位的蛋白水解环境降解生长因子,使其未能发挥应有的功能从而抑制了正常的伤口愈合过程,因此,在将来慢性伤口的治疗研究中,这些分子可能成为新的治疗靶点。Wound healing is a complex process involving several stages that include inflammation,formation of granulation tissue,reepithelialization, matrix formation and remodeling. Several growth factors play an important role in wound healing. In the acute wound,the healing process is completed by these growth factors resulting in the reestablishment of the skin＇ s barrier function. In chronic wound, the generation of a proteolytic environment by in- flammatory cells infiltrating the wound site leads to degradation of these growth factors and inhibits wound healing. Therefore, these molecules would be a new therapeutic target in future.

关 键 词：创伤愈合 生长因子 细胞因子 

分 类 号：R64[医药卫生—外科学]