不同治疗条件下对仔兔大肠杆菌病肠道显微结构的影响  

Effect of Colibacillosis on Intestine Ultrastructure of Rabbits under Different Treatment Conditions

作　　者：刘莲莲[1,2] 张应龙[1,2] 杨海莹[1,2] 马卫明[3] 曹永芝[3] 

机构地区：[1]山东商业职业技术学院,山东济南250103 [2]国家农产品现代物流工程技术研究中心,山东济南250103 [3]山东农业大学动物科学与技术学院,山东泰安271018

出　　处：《江西农业大学学报》2013年第2期238-244,共7页Acta Agriculturae Universitatis Jiangxiensis

基　　金：山东省优秀中青年科学家奖励基金(2005BS06001)

摘　　要：研究不同治疗条件下,大肠杆菌对仔兔肠道显微结构的影响。将40只兔随机分为4组,实验兔经腹腔注射大肠杆菌,兔发病后观察临床症状、大体剖检变化、病理组织学变化以及超微结构的变化。结果显示:大肠杆菌感染组(G2)兔精神沉郁,出现腹泻症状,十二指肠有散在出血点,肠壁变薄。光镜下小肠绒毛脱落、断裂。扫描电镜下肠绒毛顶端脱落、微绒毛脱落、排列杂乱、上皮细胞脱落。庆大霉素治疗组(G3)和乳酸菌素治疗组(G4)绒毛、微绒毛和上皮细胞脱落现象减轻,2种药物对兔大肠杆菌均有有效的治疗作用,乳酸菌素治疗组(G4)肠道粘膜恢复时间比庆大霉素治疗组(G3)明显缩短。表明庆大霉素和乳酸菌素对大肠杆菌感染腹泻有显著的治疗作用,在疾病恢复期乳酸菌素的治疗效果好于庆大霉素。In order to study the intestinal micro - structure in diarrhea rabbits after infection of E. coli under different treatment conditions,forty rabbits were randomly divided into four groups, intraperitoneal injection of E. coli was conducted to the test rabbits. The pathological microscopy （LM） and scanning electron microscopy （S group （G2） appeared depressied, and had diarrhea, there changes of intestinal mucosae were observed by light EM）. The results showed that, the E. coli infection were sporadic bleeding points on duodenum, the intestinal wall became thinner. Through the LM, the intestine villi were broken. Under the SEM, intestinal villi, microvillus and the epithelial cells were cluttered. The gentamicin treatment group （ G3 ） and the lactobacillus treatment group （G4） the shedding of villi, microvilli and epithelial ceils lessened. In the lactobacillus treatment group （G4） intestinal mucosae recovered much quicker than the gentamicin treatment group （ G3 ） . The results suggested that, lactolin and gentamicin could significantly control diarrhea of rabbits infected by E. coli, the effect of lactolin was better than that of gentamicin in the recovery period.

关 键 词：兔大肠杆菌 腹泻 肠道 超微结构 

分 类 号：G829.11[文化科学—体育训练]