短期大剂量普伐他汀对急性心肌梗死患者CRP、CD40L的影响  

Effect of Short-Term Large Dose of Pravastatin on the Change of C-Reactive Protein,CD40L in Patients with Acute Myocardial Infarction

作　　者：陈英[1] 刘波[1] 段小嬿[1] 吴相慰[1] 关浩增[1] 

机构地区：[1]广西壮族自治区江滨医院心血管内科,南宁市530021

出　　处：《广西医学》2013年第4期399-401,共3页Guangxi Medical Journal

基　　金：广西自然科学基金(0542060)

摘　　要：目的观察短期大剂量普伐他汀对急性心肌梗死患者C反应蛋白(CRP)、CD40L的影响。方法将72例急性心肌梗死患者按随机数字表法分为A、B两组,每组36例,A组口服普伐他汀片40 mg/d,B组口服普伐他汀片20 mg/d,治疗前及治疗3 d后分别测定CRP和CD40L。结果两组患者血清CRP和CD40L在治疗后3 d均有明显下降(P<0.05),但以40 mg普伐他汀组更为明显(P<0.01)。结论急性心肌梗死早期使用普伐他汀可抑制患者炎性反应,且大剂量效果更好。Objective To observe the effect of short-term large dose of pravastatin on the change of C-reactive protein （CRP）,CD40L in patients with acute myocardial infarction.Methods Seventy-two patients with acute myocardial infarction were divided into Group A and Group B according to the random number table：Group A（n=36） were administered orally pravastatin of 40 mg/d,and Group B（n=36） were administered orally pravastatin of 20 mg/d.The serum levels of CRP, CD40L were detected before treatment and 3 days after treatment,respectively.Results The serum levels of CRP,CD40L decreased significantly 3 days after treatment in both groups（P〈0.05）,which were superior in Group A（P〈0.01）. Conclusion The inflammatory reaction could be inhibited in acute myocardial infarction patients treated with pravastatin in the early stage,and the effect of large dose of pavastatin is better .

关 键 词：心肌梗死 普伐他汀 炎性因子 

分 类 号：R542.22[医药卫生—心血管疾病]