新城疫病毒外膜蛋白脂质体疫苗的实验研究  

Adjuvant Activity of Liposomes for NDV Envelope Proteins

作　　者：董琳琳[1] 蒋桃珍[1] 龚人雄[1] 

机构地区：[1]中国兽药监察所,北京100081

出　　处：《中国兽药杂志》2000年第4期3-5,共3页Chinese Journal of Veterinary Drug

摘　　要：本研究以冷冻干燥法制得新城疫病毒 ( NDV)外膜蛋白脂质体疫苗。两次免疫后 SPF鸡的血清 HI抗体效价结果显示 :NDV外膜蛋白脂质体疫苗免疫组的算术平均滴度要高于仅以 NDV外膜蛋白免疫组 ,二者间具有显著性差异 ( P<0 .0 5) ,且前者以 NDV强毒株攻击后的保护率达1 0 0 %,也优于单纯以The adjuvanticity of freeze dried liposomes for NDV envelope proteins tested was tested in SPF chickens. After the booster dose the liposomal NDV envelope proteins vaccine elicited a significantly higher HI titer response than the fowls injected NDV envelope proteins only.Furthermore,the liposomal vaccine groups offered a higher protective rate when challenged with ND virulent strain.

关 键 词：新城疫病毒外膜蛋白 脂质体疫苗 免疫佐剂 

分 类 号：S859.797[农业科学—临床兽医学] S858.315.3[农业科学—兽医学]