矿物药玄明粉与无水硫酸钠的构效对比研究  

Comparison on structure-efficacy between mineral drugs weathered sodium sulfate and anhydrous sodium sulfate

作　　者：游宇[1] 傅超美[1] 陈秋薇[1] 聂英军[1] 胡慧玲[1] 

机构地区：[1]成都中医药大学,四川成都611137

出　　处：《中草药》2013年第8期982-984,共3页Chinese Traditional and Herbal Drugs

基　　金：国家中医药管理局行业专项资助项目(201007011-08)

摘　　要：目的对比研究矿物药玄明粉与无水硫酸钠结构与药效差异,探索二者的作用机制。方法采用AXIOS型X射线荧光光谱法对二者结构进行比较;采用小鼠胃排空、肠推进模型和复方地芬诺酯所致便秘模型对二者药效进行比较。结果玄明粉有正交和立方两种晶型,无水硫酸钠只有正交晶型;除共有化学组成外,玄明粉还含有Al2O3、K2O、SrO、ZnO、Cl,无水硫酸钠仅有Fe2O3;药效对比实验中,发现二者对小肠运动的影响具有显著性差异(P<0.01)。结论玄明粉与无水硫酸钠在结构和药效上存在一定的差异,实验结果可为临床应用提供参考依据。Objective To compare the differences between weathered sodium sulfate （WSS） and anhydrous sodium sulfate （ASS） from structure and part potency and to explore the mechanism of action. Methods AXIOS X-ray Fluorescence Spectrometer was applied to analyze structure. We selected the model of gastric emptying, intestinal propulsion, and Compound Diphenoxylate-induced constipation. Results The result showed that there were two crystal forms： orthogonality and cube in WSS, while only orthogonality in ASS; Meanwhile, after analyzing the microelement of the two by X-ray Fluorescence Spectrometer, we found out that the common materials, yet, in WSS there were more A1203, K20, SrO, ZnO, and CI-, while there was only Fe203 in ASS. When comparing the medicative function of the two, we found out that there was an obvious difference （P 〈 0.01）. Conclusion There are some differences in structure and medicative function, which could provide the reference basis for clinical application.

关 键 词：玄明粉 无水硫酸钠 结构 药效 晶型 

分 类 号：R282.76[医药卫生—中药学]