课例《阿司匹林的制备》的微型化研究  

Study of Miniature Preparation Method of Aspirin

作　　者：覃雯[1] 张业[1] 

机构地区：[1]桂林师范高等专科学校化学与工程技术系,广西桂林541002

出　　处：《桂林师范高等专科学校学报》2013年第2期157-159,共3页Journal of Guilin Normal College

基　　金：广西新世纪教改项目工程项目(2011JGA187;2010JGZ060);桂林师范高等专科学校教改项目(NoGLSZ201007;SZJG201104)资助

摘　　要：采用微型化学实验探讨制备阿司匹林的方法,即在浓硫酸的催化下,水杨酸经过与乙酸酐发生酰化反应得到产品。实验结果表明,在无水条件和一定的反应温度(50～80℃)下,阿司匹林的微型化学实验既节约实验经费、缩短反应时间、减少污染,又可适当增加产量,有效地提高实验效率。The miniature chemical experiment of synthesizing aspirin was studied. With the catalysis of sulfuric acid, aspirin was prepared by the acetylation reaction of salicylic acid and acetic anhydride. The results indicate that, under the anhydrous conditions and at the reaction temperature 50~80℃, the miniature chemical experiment synthesizing aspirin can save experimental funding, shorten the reaction time and reduce contaminant, furthermore, it can increase the production. So the efficiency has been greatly improved.

关 键 词：阿司匹林 合成 微型实验 

分 类 号：O621.3[理学—有机化学]