依普黄酮对防治女性绝经后骨质疏松的疗效评价  

Effect evaluation of Ipriflavone on prevention osteoporosis in postmenopausal women

作　　者：李凌芳[1] 

机构地区：[1]四川省成都市温江区人民医院西药房,四川成都611130

出　　处：《中国当代医药》2013年第14期85-86,共2页China Modern Medicine

摘　　要：目的评价依普黄酮对防治女性绝经后骨质疏松的疗效。方法对46例绝经后骨质疏松患者服用依普黄酮,治疗2个月后,对治疗前后患者的骨痛进行评价,测定血生化指标碱性磷脂酶(ALP)、钙(Ca)、磷(P)和晨尿羟脯安酸(Hop/Cr)的比值。结果与治疗前相比,使用依普黄酮治疗后,患者疼痛状态明显缓解(P<0.01或P<0.05),而且腰椎、股骨颈、大转子和髋部的BMD分别增长了4.5%、5.1%、4.8%和3.9%(P<0.01或P<0.05);ALP、磷和晨尿羟脯安酸水平均显著下降,而总钙含量明显的升高(P<0.01或P<0.05)。结论依普黄酮能够促进骨的形成,对预防女性绝经后骨质疏松有较好的疗效。Objective To evaluate the effect of ipriflavone to prevent osteoporosis in postmenopausal women. Methods Fourty-six patients postmenopausal with osteoporosis were given with ipriflavone therapy for two months. Before and after treatment, the degree of pain release was evaluated. The biochemical markers, such as alkaline phosphatase （ALP）, blood calcium （Ca）, phosphate （P）, and the ratio of Hop/Cr were measured. Results After the treatment, the de- gree of pain release had been significantly relieved （P 〈 0.01 or P 〈 0.05）, the bone density of lumbar spine, femoral neck, trochanter and hip was elevated 4.5%, 5.1%, 4.8%, and 3.9% （P 〈 0.01 or P 〈 0.05）, respectively. The levels of alkaline phosphatase （ALP）, phosphate （P）, and the ratio of Hop/Cr decreased significantly, but the sum calcium （Ca） of bone increased significantly （P 〈 0.01 or P 〈 0.05）. Conclusion Ipriflavine can promote bone formation, and the effect is very important in prevention of osteoporosis in postmenopausal women.

关 键 词：绝经后 骨质疏松 依普黄酮 骨密度 

分 类 号：R683[医药卫生—骨科学]