老年朗格汉斯细胞组织细胞增生症3例诊治分析  

Experience on the clinical features and treatment of elderly Langerhans cell histiocytosis

作　　者：张旭[1] 赵翌[2] 

机构地区：[1]大连医科大学附属第二医院胸外科,辽宁大连116027 [2]大连医科大学附属第一医院肿瘤科,辽宁大连116011

出　　处：《大连医科大学学报》2013年第2期163-166,共4页Journal of Dalian Medical University

摘　　要：目的探讨老年朗格汉斯细胞组织细胞增生症患者的临床特征及治疗方法。方法收集3例经病理学证实的老年朗格汉斯细胞组织细胞增生症患者的临床资料。本文3例老年患者均以淋巴结及内脏器官侵犯为主,无皮疹,1例低热。1例行化疗,1例行放化疗,1例行放疗;观察他们的临床特征,并根据RECIST标准评价治疗疗效、CTCAE v3.0进行安全性评估、观察总体生存期。结果行放/化疗后患者的肿块缩小,生存期延长,最长26个月。主要副作用为放化疗后骨髓抑制。结论老年朗格汉斯组织细胞增生症的患者,以淋巴结及内脏器官侵犯为主,放/化疗是一种较好的治疗选择。Objective To investigate the clinical features anti treatment of the elderly Langerhans cell histiocytosis patients. Methods We collected 3 elderly clinical data, which confirmed by pathology of Langerhans cell histiocylosis. The le- sions maily affected the lymph nodes and internal organs, no rash, and one case of low fever. One patient received ehemolherapy, tree patient received radiotherapy and chemotherapy, one patient radiotherapy. We observed their clinical tealures.We evaluated treatment efficacy aecording to the RECIST criteria, safely assessment by CTCAE v3.0,and observed the patients＇s overall survival. Results The mass reduced after radiotherapy/chemotherapy, overall survival longer, up to 26 months; the main side effeet was bone marrow supprcssion after radiotherapy and chemotherapy. Conclusion The lesions mainly affected the lymph nodes and internal organs in the elderly l.angerhans cell histiocytosis patients, radiotherapy/ chemotherapy maybe is a better treatment option to them.

关 键 词：朗格汉斯细胞组织细胞增生症 临床特征 治疗 

分 类 号：R551.2[医药卫生—血液循环系统疾病]