先天性与获得性免疫在葡萄膜炎发生中病理机制的研究进展  

The pathological mechanism of innate and adaptive immunity in the development of uveitis

作　　者：刘正峰(综述)[1] 崔彦(审校)[1] 毕宏生(审校)[1] 

机构地区：[1]山东中医药大学附属眼科医院山东中医药大学眼科研究所,济南250002

出　　处：《中华实验眼科杂志》2013年第5期505-509,共5页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（81072961、81100658）;山东省自然科学基金项目（ZR2010HM048）

摘　　要：人体经常与多种病原体相接触，但并不引起疾病，这是先天性免疫功能的体现。获得性免疫能区别自身与异体病原体，通过对外周环境的控制和调节来维持机体免疫的完整性并作出适宜应答。无论是先天性免疫还是获得性免疫，机体调控机制的缺失均会导致自身免疫性疾病和机体炎症反应。大量的研究证明，尽管自身免疫性眼病和眼内自发炎症的发生有许多共同点，但却是通过不同途径完成的。从免疫反应被激活的基本机制推断，对先天性免疫和获得性免疫进行调控可影响自身免疫性炎症的发生和葡萄膜炎的进展。就先天性与获得性免疫在葡萄膜炎发生中病理机制的研究进展进行综述。Human body often contacts with different kinds of pathogens,but these pathogens do not result in disease due to innate immunity. The adaptive immunity is able to discriminate self and non-self pathogen and further maintain immunological health and appropriate response through peripheral regulatory mechanism. Whether innate immune or adaptive immune,lack of control mechanism leads to autoimmunity and autoinflanlmation. Up to now,some studies demonstrated that autoimmunity and autoinflammation have many common characteristics in intraoeular inflammation, but their mechanism relates to different molecular pathways. Hence, ophthalmologists have better understanding in the pathogenesis of uveitis. Herein, it is inferred from the basic mechanism of the activation of immunology pathway that regulation of innate and adaptive immunity might impact how autoinflammatory and autoimmune pathways contribute to disease progress in uveitis.

关 键 词：葡萄膜炎 先天性免疫 获得性免疫 病理机制 

分 类 号：R392[医药卫生—免疫学]