丙酸氟替卡松和氯雷他定治疗对儿童变应性鼻炎患者生活质量的影响  

Fluticasone propionate and loratadine granules improve the quality of life in patients with allergic rhinitis in childhood:A clinical observation

作　　者：刘继荣[1] 杨爱萍[1] 于甲瑞[1] 李元明[1] 宿川[1] 

机构地区：[1]济南市第三人民医院耳鼻咽喉科,济南250101

出　　处：《山东大学耳鼻喉眼学报》2013年第2期26-28,33,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的观察丙酸氟替卡松和氯雷他定治疗对儿童变应性鼻炎患者生活质量的影响。方法采用随机、自身前后及健康组对照的方法,应用变应性鼻炎患者生活质量问卷调查RQLQ评估。入选门诊77名儿童变应性鼻炎患者,应用丙酸氟替卡松水溶性鼻喷雾剂和氯雷他定颗粒治疗,并随访2次共4周,应用计分方法比较治疗前后患者症状和体征的变化,并于治疗前、治疗2周和4周后采用RQLQ生活质量问卷分别进行生活质量评价,评价内容包括7大项、26个项目。结果 77名患者的症状和体征总积分均有改善;治疗2周和4周后的症状和体征计分显著低于治疗前,同时治疗4周后的症状体征计分显著低于治疗2周。治疗4周后与治疗前比较,患者生活质量明显提高,接近或达到健康人水平。结论丙酸氟替卡松和氯雷他定治疗儿童变应性鼻炎疗效确切可靠,能明显提高患者的生活质量。Objective To evaluate the therapeutic effect of fluticasone propionate and loratadine granules on quality of life（QOL） in patients with allergic rhinitis in childhood. Methods 77 patients with allergic rhinitis in childhood were randomly in this study. They were compared with self-controlled and health-controlled groups. QOL was measured by u- sing rhinoconjunctivitis quality of life questionnaire（RQLQ）. Patients were investigated 2 and 4 weeks after using fluti- casone and Loratadine respectively. Symptoms were evaluated by the patients, and signs were evaluated by the investi- gators using scores under self-controlled models. RQLQ was administered at the start of treatment and 2 and 4 weeks af- ter the treatment. Results Fluticasone and loratadine improved the symptoms and signs. The 4-week scores which reached that of the health group were significantly less than the pre-treatment scores and the 2- week scores. Conclnsion Fluticasone and loratadine play an extremely important role in the treatment and improve the QOL in patients with al- lergic rhinitis in childhood.

关 键 词：变应性鼻炎 儿童 丙酸氟替卡松 氯雷他定 治疗 生活质量 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]