免疫性血小板减少症常规加个体化治疗37例观察  

Observation of conventional and individualized treatment of immune thrombocytopenia in 37 cases

作　　者：谢东[1] 王松[1] 罗永婧[1] 陈红燕[1] 谢娟[1] 王婷[1] 姜义[1] 代芳[1] 

机构地区：[1]解放军44医院消化血液科,贵阳550009

出　　处：《西南国防医药》2013年第5期505-506,共2页Medical Journal of National Defending Forces in Southwest China

摘　　要：目的探索免疫性血小板减少症(ITP)个体化治疗方法以提高疗效。方法 ITP患者共37例,男16例,女21例,年龄17～76岁;病程6个月以下24例,6个月以上13例,入院时外周血小板计数均低于50×109/L;给予单纯常规治疗(糖皮质激素+静脉用免疫球蛋白)4 w后,仍然无效的病例加用个体化治疗(环孢素A、长春新碱、达那唑、重组人血小板生长因子)3 w后,比较两组的疗效。结果常规治疗有效率为70.3%,常规加个体化治疗的有效率为91.9%,两组之间有显著差异(P<0.05)。结论对于常规治疗无效的病例,加用个体化治疗可进一步提高疗效。Objective To explore the individualized treatment on immune thrombocytopenia （ITP）in order to improve the curative effects. Methods There were 37 cases of ITP including 16 male and 21 female ones who aged from 17 to 76 years old. The course of disease was less than 6 months in 24 cases and more than 6 months in 13 ones. At the time of admission, their peripheral blood platelet count was less than 50 x 10^9/L. Four weeks after the simple conventional treatment （glucocorticoid plus intravenous immunoglobulin） ,those still invalid cases received the individualized treatment （cyclosporine A, vincristine, danazol, recombinant human platelet growth factor） for 3 w. Then comparison was made in the curative effects between the two groups. Results The effective rate of conventional treatment was 70.3% , and that of the conventional method plus individualized treatment was 91.9%. There were significant differences between the two groups （ P 〈 0.05 ）. Conclusion For the cases who are ineffective with the conventional treatment, the addition of individualized treatment can further improve the curative effect.

关 键 词：免疫性血小板减少症 个体化治疗 疗效 

分 类 号：R558.2[医药卫生—血液循环系统疾病]