不同剂量瑞舒伐他汀治疗老年高胆固醇血症的疗效和安全性比较  

Comparison of Efficacy and Safety of Different Doses of Rosuvastatin Calcium in Treating Senile Hypercholesterolemia

作　　者：徐月萍[1] 孙梁燕[1] 邹薇[1] 岑镇波[1] 楼晓清[1] 

机构地区：[1]浙江省慈溪市人民医院,浙江宁波315300

出　　处：《中国药业》2013年第8期44-46,共3页China Pharmaceuticals

基　　金：浙江省慈溪市科技局课题;项目编号:CN2009031

摘　　要：目的观察不同剂量瑞舒伐他汀钙治疗老年高胆固醇血症的疗效和安全性。方法将入选的184例患者随机分配到低、高剂量瑞舒伐他汀钙(5,10 mg/d,n=63,61)试验组和阿托伐他汀钙(20 mg/d,n=60)对照组;治疗8周后,观察3组患者的血脂变化及不良反应。结果治疗8周后,3组低密度脂蛋白胆固醇水平较基线均明显下降,高剂量试验组优于低剂量试验组及对照组(P<0.05)。高剂量试验组和对照组不良反应发生率比较,差异无统计学意义(P>0.05),低剂量试验组无不良反应发生。结论瑞舒伐他汀钙(10 mg/d)治疗原发性高胆固醇血症效果优于阿托伐他汀钙(20 mg/d),且安全性及耐受性类似。Objective To observe the efficacy and safety of different doses of rosuvastatin calcium in the treatment of senile hyperchole- strolemia. Methods A hundred and eighty- four aged patients with hypercholesterolemia were randomly divided into the low-, high- dose trial groups（rosuvastatin calcium 5,10 mg/d, n =63,61） and the control group （atorvastatin calcium 20 rag/d, n =60）. After 8- week treatment, the change of blood lipid levels and drug related adverse reactions were observed and compared among 3 groups. Results The LDL- C level ＂after 8- week treatment in each group was significantly decreased than the base line level;which in the high- dose trial group was better than the low- dose trial group and the control group. The occurrence rate of adverse reactions had no statistical difference among three groups. Conclusion The efficacy of rosuvastatiu calcium（10 mg/d） in treating senile hyperchoies- terolemia is superior to atorvastatin calcium（20 mg/d）,with the same safety and tolerance.

关 键 词：高胆固醇血症 瑞舒伐他汀钙 阿托伐他汀钙 

分 类 号：R969.4[医药卫生—药理学] R972.6[医药卫生—药学]