醒脑静注射液治疗50例脑梗死的临床分析  

Clinical Analysis of Xingnaojing Injection in Treating 50 Cases of Cerebral Infarction

作　　者：张宴斌 汪保孝 

机构地区：[1]浙江省杭州市余杭区第一人民医院神经内科,浙江杭州311100

出　　处：《中国药业》2013年第8期102-103,共2页China Pharmaceuticals

摘　　要：目的评价醒脑静注射液治疗脑梗死的临床疗效及安全性分析。方法选择医院2012年1月至12月收治的脑梗死患者100例,随机均分成两组,均给予吸氧、维持酸碱及水电解质平衡、抗凝、降颅压、降血压、降纤、改善脑循环代谢等常规对症治疗,对照组加用复方丹参注射液20 mL,治疗组加用醒脑静注射液20 mL,均加入0.9%氯化钠注射液250 mL中静脉滴注,每日1次,以两周为1个疗程。结果总有效率对照组为74.00%,治疗组为96.00%,两组差异有显著统计学意义(P<0.05);治疗组治疗前神经功能缺损评分与对照组相比差异无统计学意义(P>0.05),治疗后神经功能缺损评分显著低于对照组(P<0.05);两组患者在治疗过程中均未见明显不良反应。结论醒脑静注射液治疗脑梗死疗效显著,可有效改善患者神经功能缺损及生活质量,降低病死率,且无明显不良反应,值得临床推广。Objective To evaluate the clinical efficacy and safety of Xingnaojing Injection for the treatment of cerebral infarc- tion. Methods A hundred patients with cerebral infarction treated in our hospital from January to December 2012 were randomly divid- ed into two groups,50 cases in each group. The two groups all were given the routine symptomatic treatment of oxygen inhalation,main- taining water and electrolyte balance, anticoagulation,deereasing intracranial pressure,reducing blood pressure ,lowering fibrinogen, improv- ing cerebral circulation and metabolism. The control group was added with Compound Danshen Injection 20 mL and the treatment group was given Xingnaojing Injection 20 mL and 0. 9% Sodium Chloride Injection 250 mL by intravenous drip,once a day,with two weeks as a course of treatment. The clinical efficacies,neurologic deficit scores and incidence rates of adverse reactions after treatment were com- pared between the two groups. Results The total effective rate was 74.00% in the control group and 96. 00% in the treatment group, there was statistical difference between the two groups （P 〈 0. 05）;there was no statistical difference in the neural function defect scores before treatment between the two groups （P 〉 0.05）, but the neurological deficit scores after treatment in the treatment group were significantly lower than those in the control group,showing statistically significant difference between the two groups （P 〈 0.05 ）; the two groups had no obvious adverse reactions during treatment. Conclusion Xingnaojing Injection has remarkable effect in the treat- ment of cerebral infarction, can effectively improve the neural function defect and the quality of life of patients, reduce the mortality rate and have no obvious adverse reactions,which is worth promoting in clinical use.

关 键 词：醒脑静注射液 复方丹参注射液 脑梗死 

分 类 号：R285.6[医药卫生—中药学] R286[医药卫生—中医学]