辛伐他汀对左室肥厚和左室功能的影响  

Left ventricular hypertrophy and left ventricular function in essential hypertensive patients receiving telmisartan-based therapy with or without simvastatin

作　　者：卜彤[1] 潘秀娣[1] 曾昭华[1] 温燕杭[2] 肖霭仪[2] 陆东风[1] 

机构地区：[1]广州医学院第一附属医院心内科,510120 [2]广州医学院第一附属医院超声科,510120

出　　处：《实用医学杂志》2013年第9期1497-1499,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号:81170280);广州市科技局基金资助项目(编号:2006C13G0021)

摘　　要：目的:了解辛伐他汀对心肌肥厚及左室功能的影响。方法:未经治疗的单纯原发性高血压患者,降压达标后,超声心动图确诊合并心肌肥厚共41例。随机单盲分为两组:对照组(N组):给予以替米沙坦为基础的降压治疗;辛伐他汀治疗组(T组):在以替米沙坦为基础的降压治疗上加用辛伐他汀。观察治疗1年后的变化。结果:(1)治疗前两组血压水平均较高,组间比较P>0.05。(2)T组治疗后收缩压较N组下降更为显著;(3)1年后,N组和T组均能逆转左室肥大;T组左室射血分数明显升高[(57.50±16.41)%vs(65.43±11.60)%],P<0.01),而N组的左室射血分数无明显变化;T组的心肌肥厚和左室收缩功能改善较N组更明显(P<0.05);(4)T组患者左房内径减少(P<0.01),但是E/A比值仍较前下降,左室舒张功能仍呈下降趋势。结论:辛伐他汀对原发性高血压患者的左室肥厚和左室收缩功能不全有逆转作用。Objective To evaluate the changes of left ventricular hypertrophy and left ventricular function in essential hypertensive patients receiving telmisartan-based therapy with or without simvastatin.Method Forty-one patients with essential hypertension combined with left ventricular hypertrophy were randomized into the control group（Group N）,the telmisartan-based therapy group,and the telmisartan-based plus simvastatin therapy group（Group T）.The study period lasted for one year.Result（1）The blood pressure of the patients with simple essential hypertension combined with left ventricular hypertrophy was high;（2）The telmisartan-based plus simvastatin therapy was more effective in decreasing the systolic blood pressure than group N;（3）Afer 1-year treatment,the parameters of left ventricular hypertrophy in both two groups were improved,and the ejection fraction was elevated more significantly in group T than that in group N（57.50 ± 16.41% vs 65.43 ± 11.60%,P〈0.01）.The left ventricular hypertrophy was ameliorated and the left ventricular systolic function was improved markedly in group T;（4）The left atrium inner diameter in group T was significantly decreased（P〈0.01）,and the ratio of E /A and the left ventricular systolic function were also reduced in group T.Conclusion Simvastatin treatment could efficiently ameliorate left ventricular hypertrophy and improve the left ventricular systolic function,but it has no benefit of improving the left ventricular diastolic function.

关 键 词：高血压 辛伐他汀 心肌肥厚 左室收缩功能 左室舒张功能 

分 类 号：R541.3[医药卫生—心血管疾病]