2型糖尿病患者颈动脉内膜中层厚度及相关因素分析  

Analysis of the Relative Factors of Carotid Intima-media Thickness in Patients with Type 2 Dia- betes Meilitus

作　　者：李杰[1] 王大鹏[1] 沈毅[1] 马红[1] 

机构地区：[1]山东省青岛市市立医院干部保健三科,山东青岛266000

出　　处：《医学临床研究》2013年第4期695-697,共3页Journal of Clinical Research

摘　　要：【目的】观察2型糖尿病（T2DM）患者颈动脉内膜中层厚度（C—IMT）的情况，并分析其相关因素。【方法】入住本科的患者按照是否患有T2DM分为T2DM组（，2—53）与未合并T2DM的对照组（n=46），采用超声检查两组患者的C—IMT，并检测血尿素氮（BUN）、尿酸（uA）、肌酐（Cr）、甘油三酯（TG）、低密度脂蛋白（LDL）和尿微量白蛋白（UmAlb）水平，进行相关性分析。【结果IT2DM组患者UmAlb及LDL水平显著高于对照组（P〈0．01）；左右两侧C—IMT及斑块发生率均显著高于对照组（P〈0．05）。T2DM患者的C_IMT与U1TIAlb和UA有明显的相关性（相关系数分别为0．504，0．487；P〈0．01，P〈0．05）。【结论】T2DM患者的UmAlb、UA和C-IMT呈正相关，可作为T2DM患者动脉粥样硬化的评估指标之一。[Objective]To observe the carotid intima-media thickness（C-IMT） in patients with type 2 dia- betes mellitus（T2DM） and analyze the relative factors. [Methods]According to the patients with or without T2DM, 99 patients admitted to our department were divided into T2DM group（ n = 53） and control group without T2DM（ n = 46）. The C-IMT of patients was measured by color Doppler ultrasound. Urea nitrogen （BUN）, uric acid（UA）, creatinine（Cr）, triglyceride（TG）, low density lipoprotein（LDL） and urine micro-al- bumin（UmAlb） were detected. The correlation analysis was performed. [Resultsl The levels of UmAlb and LDL in T2DM group were significantly higher than those in control group（ P %0.01）. C-IMT and the inci- dence of plaque of left and right side in T2DM group were significantly higher than those in control group（ P %0.05）. C-IMT in T2DM patients was obviously correlated with UmAlb and UA（r=0. 504, 0. 487, P 0.01, P %0.05）. [ConclusionI UmAlb and UA in patients with T2DM are positively correlated with C-IMT and can he used as one of indicators for evaluating atherosclerosis in patients with T2DM.

关 键 词：糖尿病 2型 颈动脉 

分 类 号：R587.1[医药卫生—内分泌]