辛伐他汀对慢性阻塞性肺疾病肺功能的影响及作用机制研究  

Effect of simvastatin on pulmonary function in patients with chronic obstructive pulmonary disease in stationary phase and study on mechanism.

作　　者：蒋智敏[1] 历风元[1] 童旭芳[1] 杨美珠 粱志文 柯昌禄 

机构地区：[1]南昌市第一医院呼吸科,江西南昌330008 [2]上饶市第三人民医院肾内科,江西上饶334000

出　　处：《海南医学》2013年第9期1277-1279,共3页Hainan Medical Journal

摘　　要：目的观察辛伐他汀对慢性阻塞性肺疾病(COPD)稳定期患者肺功能及血清中炎症因子IL-6、TNF-α、NO的影响。方法将40例确诊为COPD稳定期的患者随机分为两组,对照组予常规治疗,试验组在常规治疗的基础上加用辛伐他汀20mg,每晚1次,疗程均为6个月,于治疗前后分别检测两组患者的肺功能、血清中IL-6、TNF-α、NO的水平。结果治疗前两组肺功能、血清中IL-6、TNF-α、NO的水平比较差异无统计学意义(P>0.05);实验组在治疗6个月后肺功能高于对照组(P<0.05),血清中IL-6、TNF-α水平较对照组低(P<0.05),NO水平较对照组高(P<0.05)。结论辛伐他汀能够降低COPD患者IL-6、TNF-α水平,升高NO的水平,延缓肺功能的下降。Objective To observe the effect of simvastatin on pulmonary fimction and levels of IL-6, TNF-α, NO in patients with chronic obstructive pulmonary disease （COPD） in stationary phase. Methods Forty pa- tients with COPD in stationary phase were randomly divided into simvastatin group and control group. Patients in the control group （n=20） were treated with conventional therapy, and those in the siravastatin group were given oral simv- astatin 20 mg on the basis of routine treatment, once per night. The course of treatment was 6 months. Pulmonary func- tion and levels of IL-6, TNF-α, NO were measured before and after treatment. Results The difference in the pulmo- nary function, levels of IL-6, TNF-α, NO between the two group before treatment were not statistically significant（P〈0.05）. After 6 months of treatment, the pulmonary function of the simvastatin group were significantly higher than that in the control group （P〈0.05）. Serum levels of IL-6, TNF-α in the simvastatin group were significantly lower than those in the control group （P〈0.05）, while the level of NO were significantly higher （P〈0.05）. Conclusion Sim- vastatin can reduce levels of IL-6, TNF-α in patients with COPD, elevate levels of NO, and slow the decline of lung function.

关 键 词：慢性阻塞性肺疾病 辛伐他汀 肺功能 

分 类 号：R563[医药卫生—呼吸系统]