甲基强的松龙治疗儿童手足口病临床疗效观察  

Effect of methylprednisolone on hand-foot-and-mouth disease

作　　者：赵蔚[1] 瞿志军[1] 庄桂龙[1] 邝建玉[1] 周金坊[1] 

机构地区：[1]深圳市龙岗中心医院感染科,广东深圳518116

出　　处：《海南医学》2013年第10期1524-1525,共2页Hainan Medical Journal

摘　　要：目的探讨甲基强的松龙治疗手足口病的疗效。方法将200例手足口病患儿随机分为观察组(甲基强的松龙+利巴韦林+维生素C)、对照组(利巴韦林+维生素C)。观察两组患儿的发热时间、主动进食时间、口腔溃疡愈合时间、皮疹结痂时间和药物的不良反应。结果观察组患儿退热时间、主动进食时间短于对照组,差异有统计学意义(P<0.05)。口腔溃疡愈合时间、皮疹结痂时间组间比较差异无统计学意义(P>0.05)。两组用药后均未发现有不良反应。结论短期应用甲基强的松龙治疗儿童手足口病可以缩短发热时间、提早主动进食时间,不延长病程,使用安全。Objective To observe the therapeutic effect of methylprednisolone in the treatment of hand-foot-and-mouth disease （HFMD）. Methods Two hundred children with HFMD were equally divided into the study group and the control group, with 100 cases in each group. The study group was given methylprednisolone, riba- virin and vitamin C, while the control group was given ribavirin and vitamin C. The time of defervescence, active feed- ing, ulcer healing, and skin rash retrogression were investigated. Results The time of defervescence and active feed- ing in the study group was shorter than that in the control group, with statistically significant difference （P〈0.05）. The time of ulcer healing and skin rash retrogression between the two groups showed no statistically significant difference. Conclusion Methylprednisolone is effective to treat HFMD.

关 键 词：手足口病 甲基强的松龙 治疗 

分 类 号：R725.9[医药卫生—儿科]