模拟移动床色谱拆分酮洛芬对映体的模拟研究  

Simulation Study on Separation of Ketoprofen on Simulated Moving Bed

作　　者：孙玉高[1] 来梦龙[1] 周慧君[1] 徐巍[1] 徐进[1] 

机构地区：[1]温州大学化学与材料工程学院,浙江温州325035

出　　处：《广州化工》2013年第9期55-57,60,共4页GuangZhou Chemical Industry

基　　金：浙江省温州市科技计划项目(H20100055)

摘　　要：利用平衡扩散模型对酮洛芬对映体在4区模拟移动床上的拆分进行模拟研究,考察了主要操作参数对分离效能的影响,具体包括:(a)切换时间对纯度、回收率的影响;(b)各区色谱柱配置对分离的影响;(c)Ⅱ区和Ⅲ区流量对纯度和回收率的影响。验证了模拟移动床操作参数的敏感性,对酮洛芬的中试生产具有一定的指导意义。Chiral separation of ketoprofen enantiomers using a 4 - zone simulated moving bed （SMB） consisting of 8 chromatography columns was studied by simulations. The effects of some key operating parameters on the SMB efficiency were investigated. The problems involved were effects of switching time on purity and recovery, effects of column distribution on purity and recovery, and effects of flow - rate in section Ⅱ and section Ⅲ on purity and recovery to provide guidance to the pilot scale production of ketoprofen enantiomers.

关 键 词：模拟移动床 酮洛芬 手性拆分 

分 类 号：TQ028.9[化学工程]