糖尿病肾病患者血 尿血管紧张素原的测定及意义  

The clinical effects of plasma and urinary angiotensinogen on type 2 diabetic nephropathy

作　　者：赵谭[1,2] 孙树印[2] 吴玉梅[2] 

机构地区：[1]济南大学山东省医学科学院医学与生命科学学院,山东济南250062 [2]济宁医学院附属济宁市第一人民医院,山东济宁272011

出　　处：《济宁医学院学报》2013年第2期115-117,共3页Journal of Jining Medical University

摘　　要：目的探讨血管紧张素原(AGT)对2型糖尿病肾病(DN)的影响。方法将46例DN患者分为早期糖尿病肾病组(EDN组)20例、临床糖尿病肾病组(CDN组)26例,另有32例为正常对照组(NC组),采用ELISA法检测各组血清和尿中的AGT水平。结果 1)EDN组、CDN组较NC组血清AGT水平明显升高,有显著性差异(F值:54.327,P<0.05),而EDN组、CDN组之间无显著性差异;与EDN组比较,CDN组尿AGT水平高,NC组低,各组间有显著性差异(F值:207.113,P<0.05)。2)2型糖尿病肾病患者的血清AGT水平与尿AGT水平无相关性。结论尿血管紧张素原可能是反映2型糖尿病肾病肾功能损害程度的指标。Objective To study the effect of angiotensinogen （AGT）on type 2 diabetic nephropathy （DN） ~ Methods 46 cases patients of DN were divided into 20 cases of early phase DN（EDN）, 26 cases of clinic phase DN（CDN） ,another 32 cases for normal control （NC）, whose plasma and urinary AGT was measured by ELISA. Results 1）Plasma AGT levels in the EDN group and CDN group was significantly higher than the NC group（F..54. 327,P〈0.05）. Urinary AGT levels in the EDN group was significantly higher than the NC group, and CDN group was significantly higher than the EDN group（F.. 207.113, P〈0.05）. （2）Plasma AGT levels was no significant corre- lated with urinary AGT levels. Conclusion Urinary AGT can be an item to show the damage degree of type 2 DN.

关 键 词：糖尿病肾病 血管紧张素原 

分 类 号：R587.1[医药卫生—内分泌]