活血化瘀法治疗结核性胸膜炎患者胸膜增厚的疗效观察  

Therapeutic Effect of Therapy of Activating Blood Circulation to Remove Stasis for Pleural Thickening in Tuberculous Pleurisy Patients

作　　者：张伟[1] 董洪珍[1] 谢慧文[1] 刘柯兵[1] 廖慧丽[1] 温敏勇[1] 

机构地区：[1]广州中医药大学第一附属医院,广东广州510405

出　　处：《广州中医药大学学报》2013年第3期302-304,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省科技计划项目(编号:2010B030700064)

摘　　要：【目的】观察活血化瘀法治疗结核性胸膜炎患者胸膜增厚的疗效。【方法】将60例符合条件的结核性胸膜炎患者随机分为治疗组和对照组各30例,住院期间治疗组给予常规治疗(抗结核药物+胸腔穿刺抽液术)结合活血化瘀中药治疗,对照组仅给予常规治疗(抗结核药物+胸腔穿刺抽液术),疗程(14±7)d。出院后治疗组口服抗结核药物+活血化瘀中成药,对照组只用抗结核药物,疗程(56±7)d。观察2组治疗前后胸水中纤维蛋白原(FIB)、胸膜厚度的变化情况。【结果】(1)治疗后2组的FIB水平均显著下降,与治疗前比较差异均有统计学意义(P<0.05或P<0.01),且治疗组的下降作用优于对照组(P<0.01)。(2)治疗后2组患者的胸膜显著增厚,与治疗前比较差异均有统计学意义(P<0.05或P<0.01),但治疗组治疗后胸膜的增厚程度显著低于对照组(P<0.01)。【结论】活血化瘀中药能有效降低结核性胸膜炎患者胸水中纤维蛋白原(FIB)的含量,明显减轻胸膜增厚的程度,改善疾病的预后。Objective To observe the therapeutic effect of therapy of activating blood circulation to remove stasis for pleural thickening in tubereulous pleurisy patients. Methods Sixty qualified tuberculous pleurisy inpatients were equally randomized into two groups. Treatment group was given conventional treatment such as antituberculosis drugs and thoracentesis, and also given oral use of the decoction of Chinese herbal medicine for activating blood circulation to remove stasis. The control group was given conventional treatment alone. The treatment lasted 14±7 days during the hospitalization. After discharge, the treatment group took antituberculosis drug and Chinese patent medicine for activating blood circulation to remove stasis, and the control group took antituberculosis drug alone. The post-discharge medicinal treatment lasted 56±7 days. The changes of fibrinogen （FIB） level in the pleural fluid and the pleural thickness were observed in both groups before and after treatment. Results （1） The FIB level was decreased in both groups, the difference was significant compared with that before treatment （P 〈0.05 or P 〈0.01）, and the decrease of FIB level in the treatment group was superior to that in the control group （P 〈0.01）. （2） The pleura became thick to some degrees in both groups after treatment （P 〈0.05 or P 〈 0.01 compared with that before treatment）, but the thickening was less in the treatment group （P 〈0.01）. Conclusion Chinese herbal medicine for activating blood circulation to remove stasis can improve the prognosis of tuberculous pleurisy patients by decreasing FIB level in the pleural fluid and by reducing the pleural thickening.

关 键 词：结核性胸膜炎 中药疗法 胸膜增厚 中药疗法 活血化瘀法 

分 类 号：R521.7[医药卫生—内科学]