银杏叶提取物对颅内血管疾病手术患者超氧化物歧化酶及丙二醛的影响  

Effects of Ginkgo biloba extract on SOD and MDA in intracranial vascular diseases operation

作　　者：金文香[1] 黄焕森[1] 阮林[1] 庄越[2] 

机构地区：[1]广州医学院第二附属医院麻醉科,广州510260 [2]广州开发区医院麻醉科,510730

出　　处：《广东医学》2013年第7期1047-1049,共3页Guangdong Medical Journal

基　　金：广州市中医药科技项目(编号:20112233010003)

摘　　要：目的通过观察银杏叶提取物预处理前后患者超氧化物歧化酶(SOD)、丙二醛(MDA)等指标的变化,探讨银杏叶提取物在颅内血管手术围术期脑保护的作用。方法择期行颅内血管手术成年患者40例,分为银杏叶治疗组(Y组)和对照组(D组),每组20例。两组均采用静吸复合全麻。麻醉诱导后,Y组经静脉滴注银杏叶提取物注射液1mg/kg(用生理盐水250mL稀释),30min滴完;D组同速度输入等量生理盐水。分别于手术前(T0)、手术1h(T1)、手术2h(T2)、手术6h(T3)、手术后12h(T4)抽取颈静脉球部血测SOD、MDA。记录两组患者手术后12h(T4)GCS评分以及术后恢复情况。结果 Y组T2、T3的SOD较T0升高,T2、T3的MDA较T0降低,但差异无统计学意义(P>0.05)。D组T2、T3、T4的SOD较T0降低,T2、T3、T4的MDA较T0升高明显(P<0.05)。组间比较,T2、T3、T4的SOD较D组明显升高(P<0.01),Y组T2、T3、T4的MDA较D组明显降低(P<0.01)。两组T4的GCS评分比较差异无统计学意义(P>0.05)。结论在颅内血管疾病手术中给予银杏叶提取物预处理具有脑保护的作用,且围术期并发症少,手术预后良好。Objective To investigate the perioperative cerebral protective effects of Ginkgo biloba extract for intracranial vascular operation on SOD and MDA. Methods Forty patients scheduled for elective intracranial vascular operation under general anesthesia were enrolled and randomly allocated into two groups （n = 20） , Group Y and Group D. After the induction of anesthesia, intravenous injection of Ginkgo biloba extract （1 mg/kg） and placebo saline were given to the participants in Group Y and D, respectively. The SOD and MDA from jugular bulb blood before operation （T0） , and at the 1st （T1）, the 2nd （T2）, the 6th hour of operation （T3）, and 12 hours after operation （T4）. The GCS was recorded at T4. Results Minor increase of SOD and reduction of MDA in Group Y at T2 and T3 were revealed （P 〉 0.05 ）. However, significant reduction in SOD and elevation of MDA were revealed in Group D at T2, T3, and T4 （ P 〈 0.05 ）. There was also significant differences in SOD and MDA between the 2 groups at T2, T3, and T4 （P 〈0. 01 ）. No significant difference in GCS between the two groups was recorded （ P 〉 0. 05 ）. Conclusion Ginkgo biloba extract provides neuroprotective effects in intracranial vascular disease operation.

关 键 词：银杏叶提取物 颅内血管疾病手术 超氧化物歧化酶 丙二醛 

分 类 号：R282.71[医药卫生—中药学]