玉竹提取物B对肿瘤的抑制作用  

Inhibitory action of EB-PAOA on tumor

作　　者：潘兴瑜[1] 张明策[1] 李宏伟[1] 李淑华[1] 李岩[2] 赵莹[2] 

机构地区：[1]锦州医学院免疫与微生物学教研室,锦州121001 [2]锦州医学院附属一院,锦州121000

出　　处：《中国免疫学杂志》2000年第7期376-377,共2页Chinese Journal of Immunology

基　　金：辽宁省教委资助!93130402

摘　　要：目的：研究玉竹提取物B（ExtractionBofpoly－gonatumodoratum，EB-PAOA）对肿瘤的抑制作用。方法：检测肿瘤细胞株CEM增殖和表面分子表达以及观察对小鼠S－180移植瘤的抑制作用。结果：玉竹提取物B10－3ml－1（V/V，以下同）浓度对CEM的增殖有显著的抑制作用，并促进CEM表面分子HLA-I分子、CD2和CD3的表达，尤其对CD2分子的表达作用更为显著，提高了CEM的分化程度。玉竹提取物B对S－180移植小鼠足垫所形成的移植瘤有明显的抑制作用，对移植瘤生长的抑制百分率（Inhibitorypercentage,IP）达68.5％（P＜0．01）；玉竹提取物B10-4ml－1的浓度对S-180腹腔移植的荷瘤小鼠可延长存活期达（10.7±3。8）d，存活率达20％。结论：玉竹提取物B具有显著的抗肿瘤作用。Objective: To research the inhibitory action of EB-PAOA on tumor. Methods: To assay for the proliferation of CEM and the expression surface molecule in CEM cells. To observe the inhibitory action of EB-PAOA on the S-180 murine tumors in vivo. Results: In 10-3ml-1 (v/v) concentration, EB-PAOA notably inhibits the proliferation of CEM cells and the promotes HLA-I molecule, CD2 and CD3 expression of CEM. Particularly, EB-PAOA has great influence on CD2 expression of CEM. EB-PAOA has great inhibitory action on S-180 murine tumors in the foot plate. The IP of EB-PAOA on S-180 murine tumors in the foot plate rises to 68.5% (P < 0.01). The survival period of S-180 murine tumors in the abdominal cavity is prolonged by EB-PAOA is 10. 7 ± 3. 8 d. Its survival percentage rises 20%. Conclusion: EBPAOA has great antitumor action.

关 键 词：玉竹提取物B 中药 免疫调节剂 抗肿瘤作用 

分 类 号：R286.95[医药卫生—中药学]