Nanog在肺癌中的表达及对吉西他滨联合顺铂化疗疗效的影响  

Expression of Nanog in lung cancer and its influence on chemotherapic effect of cisplatin combined with gemcitabine

作　　者：骆梅青[1] 卜庆[1] 曹轶林[1] 郑桂银[1] 伍爱华[1] 施朕善[1] 

机构地区：[1]桂林医学院附属医院肿瘤内科,广西桂林541001

出　　处：《现代医药卫生》2013年第9期1281-1282,共2页Journal of Modern Medicine & Health

基　　金：广西壮族自治区卫生厅基金资助项目(Z2011171)

摘　　要：目的探讨中晚期(Ⅲ、Ⅳ期)肺癌患者Nanog的表达及对吉西他滨联合顺铂化疗疗效的影响。方法采用免疫组化法检测62例肺癌患者Nanog的表达情况,研究其表达情况对吉西他滨联合顺铂化疗疗效的影响。结果 62例晚期肺癌患者中Nanog表达阳性30例(48.4%),吉西他滨联合顺铂化疗有效组32例患者中Nanog表达阳性9例(28.1%),阴性23例(71.9%);无效组30例患者中Nanog表达阳性21例(70.0%),阴性9例(30.0%)。无效组患者Nanog表达阳性率明显高于有效组(χ2=10.872,P=0.001)。结论 Nanog表达增强可导致肺癌患者对吉西他滨联合顺铂化疗不敏感,检测Nanog对临床制订肺癌个体化治疗方案有一定参考价值。Objective To investigate the the expression of Nanog in advanced lung cancer（stage Ⅲ and Ⅳ）and its influence on the chemotherapeutic effect of cisplatin combined with gemcitabine.Methods The Nanog expression in 62 patients with lung cancer was detected by immunohistochemical method to study its influence on the curative effect of cisplatin combined with gemcitabine chemotherapy.Results Among 62 patients of middle-late stage lung cancer,30 cases（48.4%） were positive expression of Nanog.Among 32 cases in the effective group of cisplatin combined with gemcitabine chemotherapy,9 cases（28.1%） were positive expression of Nanog and 23 cases（71.9%） were negavie expression of Nanog.Among 30 cases in the ineffective group,21 cases（70.0%） were positive expression of Nanog and 9 cases（30.0%） were negavie expression of Nanog.The positive expression of Nanog in the ineffective group was significantly higher than that in the effective group（P=0.001）.Conclusion The increased Nanog expression may cause the non-sensitive to the chemotherapy of cisplatin combined with gemcitabine in lung cance.Detecting the Nanog expression has certain reference value for making the individualized clinical treatment scheme in lung cancer patients.

关 键 词：肺肿瘤 基因表达 治疗结果 NANOG 化疗 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]