氟中毒大鼠骨骼X线动态观察及硒的影响  

Dynamically observed skeletal X-ray in rats with chronic fluorosis and effects of selenium

作　　者：边建朝[1] 李亨祥[1] 刘源[1] 纪庆宪[1] 咸树梅[1] 叶平[1] 

机构地区：[1]山东省地方病防治研究所,山东济南250014

出　　处：《中国地方病学杂志》2000年第4期260-261,共2页Chinese Jouranl of Endemiology

基　　金：山东省卫生厅资助!项目 ( 92 0 2 4)

摘　　要：目的　观察氟中毒大鼠骨 X线改变及硒的影响。方法　 2个组 Wistar大鼠饮 1.5 8和 2 .6 3m mol/ L氟水 ;2个组鼠饮氟水加饲 2 .0 mg/ kg硒饲料。每 2个月用钼靶 X线摄骨片共计 6次。实验 14个月时测血、尿、骨氟。结果　氟中毒大鼠血、尿、骨氟升高。骨 X线改变以骨盆骨结构异常出现最早 ,其次为腰椎、尾骨 ;前、后肢改变晚且较少 ;前肢显现骨间膜骨化 ,且晚于骨结构改变。实验 8个月发生早期氟骨症征象。氟加硒大鼠血、骨氟降低 ;骨结构异常及氟骨症出现的时间推迟 ,例数减少。结论　氟中毒大鼠骨 X线改变应以骨盆为重点观察部位 ,大鼠氟中毒中、晚期发生氟骨症。一定浓度范围内的硒拮抗高氟 ,延缓和降低氟骨症的发生。Objective To observe trend of skeletal radiography in rats with chronic fluorosis and effect of selenium.Methods Two groups of Wistar rats were fed with normal fodder and high concentration of NaF water (1.58,2.63 mmol/L fluorine,F) and two groups with selenite fodder(2.0 mg/kg selenium,Se) and high F for 14 months.The rats were photographed by means of radiography with molybdenum target tubes biomonthly total 6 times and the contents of urine,serum and bone F in the rats were examined in 14 months.Results Urine,serum and bone F in rats with fluorosis increased.Concerning bone X-ray changes,abnormalities were observed first in pelvis,then in lumbar vertebrae,finally in thoracic and pectoral limbes.Early skeletal fluorosis was found in 8 months.There was a positive correlation between concentration of F in drinking water and degree skeletal fluorosis and of abnormal bone struture.After supplement of Se,serum and bone F decreased.Abnormal bone structure and skeletal fluorosis were reduced.Conclusions Pelvie could be refered as essential observation section by radiography and skeletal fluorosis appeared in the middle and late period of fluorosis.Certain concentration of Se could antagonize high F,delay and decrease the occurrence of skeletal fluorosis in rats with fluorosis.

关 键 词：氟中毒 骨骼 硒 X线诊断 

分 类 号：R599[医药卫生—内科学]