抗Sa和抗CCP抗体对类风湿关节炎诊断意义的比较  

Compare Anti-Sa Antibody and Anti-CCP Antibody with Diagnostic Significane of Rheumatoid Arthritis

作　　者：王爱雪[1] 武丽君[1] 刘艳慧[1] 孟新艳[1] 李彩萍[2] 

机构地区：[1]新疆维吾尔自治区人民医院风湿免疫科,新疆乌鲁木齐830001 [2]新疆石河子大学医学院第一附属医院,新疆石河子832000

出　　处：《新疆医学》2013年第2期23-25,共3页Xinjiang Medical Journal

基　　金：新疆维吾尔自治区自然科学(项目编号:2009211A25)

摘　　要：目的:探讨抗Sa和CCP抗体对类风湿关节炎诊断意义的比较及其联合检测的意义。方法:采用ELISA法检测抗Sa抗体和抗CCP抗体。结果:抗Sa抗体和抗CCP抗体对RA特异性和敏感性分别为97.26%和60.67%、98.63%和92.13%,抗CCP抗体较抗Sa抗体敏感性高(P<0.05),两种抗体联合检测对RA诊断的特异性高达100%,敏感性为60.67%。抗Sa抗体阳性组中疼痛肿胀关节数大于阴性组(P<0.05),抗CCP阳性组中疼痛肿胀关节数及ANA阳性率大于阴性组(P<0.05)。结论抗CCP抗体敏感性高于抗Sa抗体,二者联合检测可以进一步提高RA诊断特异性。Objective To compare the anti-Sa antibody, anti-CCP antibody and analyze and detect the diagnostic significane of the anti-Sa antibody, anti-CCP antibody in patient with RA. Methods anti-Sa antibody, anti-CCP antibody were deteceted by ELISA. Results The specificitiy and sensitivity of anti-Sa antibody, anti-CCP antibody wet,. 97.26% and 60.67%,98.63% and 92.13%.The sensitivity of anti-CCP antibody were higher than anti-Sa antibody. The RA patients with anti-Sa were statistically different from the patients without this antibody in counts of joints with pain and swelling; The RA patients with anti-CCP were statistically different from the patients without this antibody in counts of joints with pain and swelling,and in male of antinuclear antibody. Conclusion The sensitivity of anti-CCP antibody were higher than anti-Sa antibody.

关 键 词：类风湿关节炎 抗SA抗体 抗CCP抗体 联合检测 

分 类 号：R593.22[医药卫生—内科学]