基底外侧杏仁核微量注射吗啡和纳络酮对大鼠睡眠的影响  

Effects of microinjection of morphine and naloxone into basolateral amygdaloid nucleus on sleep of the rats

作　　者：何延龙[1] 高隽[1] 赵乐章[1] 钟明奎[1] 王敏[1] 朱国庆[1] 

机构地区：[1]安徽医科大学生理教研室,合肥230032

出　　处：《安徽医科大学学报》2000年第3期194-196,共3页Acta Universitatis Medicinalis Anhui

摘　　要：目的　观察基底外侧杏仁核 (BLA)内注射吗啡和纳络酮对大鼠睡眠的影响。方法　多导睡眠描记术和杏仁核微量注射。结果　BLA注射吗啡可增加觉醒 ,减少慢波睡眠和总睡眠时间 ,而阿片受体阻断剂纳络酮引起的作用则与之相反 ,并可完全阻断吗啡的作用。结论　BLA应用外源性阿片受体激动剂抑制慢波睡眠 ,而阻断内源性阿片受体活动可促进慢波睡眠。Objective\ To investigate the effects of microinjection of morphine and naloxone into basolateral amygdaloid nucleus(BLA) on sleep of rat. Method\ Polysomnography(PSG) and nucleus amygdalae microinjection. Results\ Morphine enhanced wakefulness, but decreased slow wave sleep(SWS) and total sleep time(TST), while naloxone, the antagonist of the opiate receptors, reduced the opposite results and could stop the effect of morphine. Conclusion\ The microinjection of antagonist of the opiate receptors into BLA causes SWS decreased, but SWS is increased when the activity of the opiate receptors is inhabitted.

关 键 词：吗啡/药理学 纳络酮/药理学 杏仁核/药物作用 睡眠/药物作用 觉醒/药物作用 多导睡眠描记术 

分 类 号：R338.63[医药卫生—人体生理学] R965[医药卫生—基础医学]