产妇血、羊水和新生儿脐血瘦素水平与其体重关系的研究  

Study on Relationship between Levels of Leptin in Maternal Blood,Amniotic Fluid,and Umbilical Blood and Newborn′s Weight

作　　者：刘先俊[1] 漆洪波[2] 刘方欣[1] 胥勋平 

机构地区：[1]重庆医科大学,400016 [2]重庆医科大学第二临床学院妇产科 [3]重庆市愉中区防疫站

出　　处：《中华妇产科杂志》2000年第7期396-398,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的　探讨产妇血、羊水和新生儿脐血中的瘦素水平与其体重的关系。方法　采用放射免疫法 ,分别检测 34例产妇血、羊水及新生儿脐血的瘦素水平 ,并对其结果进行相关性分析。结果　 (1)产妇血、羊水、新生儿脐血中瘦素水平分别为 (2 6 .6± 12 .2 ) μg/L、(12 .3± 9.8) μg/L、(18.7±14.8) μg/L ;(2 )新生儿体重与产妇血、羊水、新生儿脐血中的瘦素水平有明显相关性 ,相关系数分别为 0 .5 3(P <0 .0 1)、0 .73(P <0 .0 1)、0 .6 7(P <0 .0 1) ;(3)产妇血瘦素水平与产妇体重有明显相关性 ,相关系数为 0 .6 1(P <0 .0 1) ;(4)羊水与新生儿脐血中的瘦素水平也有明显相关性 ,相关系数为 0 .72 (P<0 .0 0 1) ;(5 )羊水、新生儿脐血中的瘦素水平与母亲体重无明显相关性 ,相关系数分别为 0 .2 2、0 .18(P均 >0 .0 5 )。结论　检测妇女妊娠过程中血液和羊水中的瘦素水平 。Objective To explore the relationship between leptin′s quantity in maternal blood, amniotic fluid, umbilical blood and maternal and newborn′s weights. Methods Levels of leptin in maternal blood, amniotic fluid, and umbilical blood of 34 pregnant women were detected by radioimmunoassay (RIA) method. Results were analyzed by the correlative analysis. Results (1) Leptin can be detected either from maternal blood or amniotic fluid or umbilical blood. (2) There was an obvious correction between newborn′s weight and leptin′s quantity of maternal blood (relative coefficient r =0.53, P <0.01), amniotic fluid ( r =0.73, P <0.01) and umbilical blood ( r =0.67, P <0.01). (3) There was an obvious correction between maternal weight and leptin′s quantity of maternal blood ( r =0.61, P <0.01). (4) There was an obvious correction between leptin′s quantity of amniotic fluid and umbilical blood ( r =0.72, P <0.001). (5) There was not obvious correction between maternal weight and leptin′s quantity of amniotic fluid and umbilical blood ( r =0.22, r =0.18, respectively. P >0.05). Conclusion It may be of important significance in detection of leptin′s quantity in amniotic fluid and maternal blood in pregnant women for predicting the weight and growth of newborns.

关 键 词：蛋白质类 胎血 羊水 妊娠 

分 类 号：R446.11[医药卫生—诊断学]