Palladium-Catalyzed Cyclocarbonylation of 2-Halobenzaldehyde and Hydrazines： A Facile Synthesis of 2-Aminoisoindolin-l-ones  

作　　者：Chao Han Yang Shen Ping Lu Yanguang Wang 

机构地区：[1]Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, China

出　　处：《Chinese Journal of Chemistry》2013年第2期182-186,共5页中国化学（英文版）

基　　金：the National Natural Science Foundation of China

摘　　要：An efficient procedure for the synthesis of 2-aminoisoindolin-l-ones via a palladium-catalyzed three-component reaction of 2-halobenzaldehydes, hydrazines and carbon monoxide is reported. This cyclocarbonylation process can be performed smoothly under 1 atmospheric pressure of carbon monoxide to afford 2-aminoisoindolin- 1-ones in moderate to excellent yields.An efficient procedure for the synthesis of 2-aminoisoindolin-l-ones via a palladium-catalyzed three-component reaction of 2-halobenzaldehydes, hydrazines and carbon monoxide is reported. This cyclocarbonylation process can be performed smoothly under 1 atmospheric pressure of carbon monoxide to afford 2-aminoisoindolin- 1-ones in moderate to excellent yields.

关 键 词：CYCLOCARBONYLATION 2-aminoisoindolin-l-ones multicomponent reactions HETEROCYCLES 

分 类 号：TQ225.242[化学工程—有机化工] O627.42[理学—有机化学]