Ligand-Free Synthesis of 1,4-Disubstituted-l,3-diynes by Iron/Copper Cocatalyzed Homocoupling of Terminal Alkynes  

作　　者：Peipei Wang Xiaoyan Liu Songlin Zhang 

机构地区：[1]Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science of Soochow University, Suzhou, Jiangsu 215123, China

出　　处：《Chinese Journal of Chemistry》2013年第2期187-194,共8页中国化学（英文版）

基　　金：We are grateful for financial support from the National Natural Science Foundation of China，the Priority Academic Program Development of Jiangsu Higher Education Institutions

摘　　要：A simple and efficient protocol for Fe/Cu cocatalyzed oxidative homocoupling reaction of terminal alkynes to symmetrical 1,4-disubstituted-l,3-diynes was presented. The results showed that both CuBr and FeC13 played erucial roles in the reaction. It is noteworthy that this protocol employs mild, efficient, aerobic and ligand free conditions. The alkynes, including aromatic, heteroaromatic and aliphatic alkynes, were transformed into the corresponding 1,3-diynes in good to excellent yields.A simple and efficient protocol for Fe/Cu cocatalyzed oxidative homocoupling reaction of terminal alkynes to symmetrical 1,4-disubstituted-l,3-diynes was presented. The results showed that both CuBr and FeC13 played erucial roles in the reaction. It is noteworthy that this protocol employs mild, efficient, aerobic and ligand free conditions. The alkynes, including aromatic, heteroaromatic and aliphatic alkynes, were transformed into the corresponding 1,3-diynes in good to excellent yields.

关 键 词：catalysis COPPER IRON 1 3-diyne LIGAND-FREE 

分 类 号：O623.11[理学—有机化学] O623.124[理学—化学]