Approach for the Direct Synthesis of β-Dichlorosubstituted Acetanilides Using Iodine Trichloride （ICI3） as the Oxidant and Catalyst  

作　　者：Qing Zhang Weibing Liu Cui Chen Liquan Tan 

机构地区：[1]School of Chemistry and Life Science, Guangdong University of Petrochemical Technology, Maoming, Guangdong 525000, China

出　　处：《Chinese Journal of Chemistry》2013年第4期453-455,共3页中国化学（英文版）

摘　　要：A reliable method for direct synthesis of β-dichlorosubstituted acetanilides is reported. The key transformation involves the oxidative and catalytic cleavage of a carbon-carbon bond in the presence of iodine trichloride （ICl3）. In this protocol ICl3 is used not only as the catalyst but also as the oxidant which widely broadens the scope of its ap- plication in organic synthetic chemistry.A reliable method for direct synthesis of β-dichlorosubstituted acetanilides is reported. The key transformation involves the oxidative and catalytic cleavage of a carbon-carbon bond in the presence of iodine trichloride （ICl3）. In this protocol ICl3 is used not only as the catalyst but also as the oxidant which widely broadens the scope of its ap- plication in organic synthetic chemistry.

关 键 词：iodine trichloride （ICl3） cleavage of carbon-carbon bond 3-oxo-N-phenylbutanamides β-dichlorosub-stituted acetanilides 

分 类 号：TQ225.52[化学工程—有机化工] O625.632[理学—有机化学]