急性A型主动脉夹层合并急性肺损伤患者白介素血清浓度临床观察  

Observation of serum IL-6,8,10,19 level in type A acute aortic dissection with ALI

作　　者：邢晓燕[1] 孙立忠[1] 刘楠[1] 郑军[1] 潘旭东[1] 乔志钰[1] 张明[1] 朱俊明[1] 

机构地区：[1]首都医科大学附属北京安贞医院心外科5病房,北京100029

出　　处：《中国急救复苏与灾害医学杂志》2013年第5期414-416,共3页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：国家自然科学基金（81000135）;国家自然科学基金（30972868）;北京市自然科学基金项目（KZ201010025107）;首都医学科研发展基金（2007-2017）;首都医科大学基础一临床科研合作基金（11021202）;首都医学科研发展基金（2011-2006-05）;北京市科学技术委员会-国际科技合作交流专项（2012DFA31110）

摘　　要：目的观察急性A型主动脉夹层合并急性肺损伤患者白介素血清浓度变化。方法随机采集45例急性A型主动脉夹层术前患者血清样本。健康对照组15例。测定血清样本血清IL-6，8，10，19浓度，并进行血气分析。统计分析采用SPSS17．0软件，行秩和检验和t检验。结果急性A型主动脉夹层合并急性肺损伤组较非急性肺损伤组患者ICU时间和呼吸机时间明显延长，差异有统计学意义（P〈0．05）。急性A型主动脉夹层患者与健康对照组相比，血清IL-6，8，10和19浓度明显升高，差异有统计学意义（P〈0．05）；急性肺损伤血清浓度高于非急性肺损伤患者，差异有统计学意义（P〈0．05）。结论白介素-6、8、10和19可能与急性A型主动脉夹层及合并急性肺损伤患者的病理损伤相关。Objective To observe serum interleukin （IL）-6,8,10,19 （IL-6,8,10,19） level in a group of patients with type A cute aortic dissection, and explore the clinical correlation between the change of inflammatory biomarkers and type A acute aortic dissection with acute lung injury （ALI）. Methods A total of 45 serum samples of type A acute aortic dissection were randomly collected from 33 males and 12 females, between age 20 and 74, in between May and November, 2011. The control group was created with 15 healthy people. Peripheral venous blood 5 ml, peripheral artery blood 1.5 ml, and artery blood were drawn and sent for arterial blood gas analysis; venous blood was set for 30 minutes before being centrifuged, and then serum was extracted respectively and saved in-81 ℃ refrigerator; they were tested for serum IL-6,8,10,19 by adopting ELSIA test kit. Based on the results from blood gas analysis, the calculation of oxygenation index （MRI）, oxygenation index （MRI） = arterial oxygen tension （PaO2）/inspired oxygen fraction （FiO2）. The acute lung injury group was identified as oxygenation index （MRI） 〈 300. The non-acute lung injury group was identified when the index ≥ 300. Statistical analysis was processed by SPSS 17.0 software. Results It demonstrated no significant difference between the two groups in age, sex, time of onset, body mass index, cardiac ejection fraction. However, the significant difference was found in ICU time, ventilation time and mortality （P〈0.05, table 1）. Comparing with the control group, serum interleukin （IL-6,8,10,19） of Acute type A aortic dissection patients was significant higher （P〈0.05）; as well as their serum interleukin （IL-6,8,10,19） with ALI （P 〈 0.05）. Comparing with non-ALI group, serum interleukin （IL-6,8,10,19） of Acute type A aortic dissection with ALI patients were significant higher （P〈 0.05, table 1）. Conclusion While the serum IL-6, 8,10,19 level of Acute type A aortic dissection increased, the serum IL-6, 8

关 键 词：急性A型主动脉夹层 急性肺损伤 白介素 

分 类 号：R446.9[医药卫生—诊断学]