胺碘酮预防预激综合征患者射频消融时心房颤动的临床对照研究  

A Randomized Controled Trial of Amiodarone in Preventing Atrial Fibrillation During Catheter Ablation in Patients with Preexcitation Syndrome

作　　者：马宇凌[1,2] 李丽娟 蔡洪波 郭莉 铁晓军 

机构地区：[1]宁夏回族自治区吴忠市人民医院,宁夏吴忠751100 [2]兰州大学第一附院心内科,甘肃兰州730000

出　　处：《医学信息》2013年第8期116-116,共1页Journal of Medical Information

摘　　要：目的探讨胺碘酮对预激综合征（Wolff-parkinson—Whitesyndrome，W—P—W）患者房室旁路电生理特性的影响及其在射频消融术中预防房颤发生的作用。方法2005年1月-2010年12月，住院治疗有阵发性房颤史的W-p—W患者99例，采用随机数字表分为实验组：51例。射频消融术前2w口服胺碘酮0．2g,bid：对照组：48例，口服安慰剂对照。术中电生理测定旁路前传、逆传不应期（ERP），记录术中房颤的发生次数和房颤持续时间，发作时的心室率及手术时阉。结果实验组与对照组比较，实验组术中旁路前传、逆传ERP明显延长[（332±92）vs（221±32）ms，P〈O001；（311±52）vs（233±26）ms,P〈0．0011；房颤发作次数明显降低（132％vs521％，P〈0．01）；房颤发作时间明显缩短[（7．6±3．1）w（15．2±6．9）rain，P〈0．01]；房颤发作时心室率明显减慢[（119±31）vs（156±29）次／min，P〈O．051；手术时问明显缩短f（121±51）vs（161±56）min．P〈0．051。结论胺碘酮可以有效预防w—P—W射频消融术中心房颤动的发生．缩短手术时间．降低术中风险．Objective To evaluate the effects of amiodarone on electrophysiological variables of accessory pathways and it＇s value in preventing atrial fibrillation during catheter ablation in patients with wolff-parkinson-white syndrome （W-P-W）. Methods From January 2005 to December 2010,99 patients of preexcitation with paroxysal atrial fibrillation was divided in to two grous one is amiodarone the other is control.Amiodarone was admitted at the dosage of 0.2g bid 2 weeks before the operation in 51 patients, while the other 48 eases taking placebo served as control.The anterograde and retrograde effective refractory period （ERP）of accessory pathway ,atrial fibrillation occurrence,persisting time ,ventrieular rate during episode and the time of operation were recorded. Results The anterograde and retrograde ERP of accessory pathway were significant reduced in amiodarone group [（332±92）vs（221±32）ms,P〈0.001;（31 l±52）vs（233±26）ms,P〈0.001].The occurrence and persising time of atrial fibrillation was significantly reduced in the amiodarone group[13.2%vs52.1%,P〈0.01;（7.6±3.1）vs（15.2±6.9）rain,P〈0.01].The ventricular rate was also significant reduced in the amiodarane group[（119±31 ）vs（ 156±29）times per minute ,P〈0.05].The time of procedure was much shorter in the amiodarone group[（121±51）vs（161±56）min,P〈0.05]. Conehlsion The amiodaronc can effectively reduce the incidence of atrial fibrillation during catheter ablation in Patients with preexcitation syndrome and also can reduce the risk of operatin by shortern the time procedure.

关 键 词：预激综合症 胺碘酮 心房颤动 

分 类 号：R942.2[医药卫生—药剂学]