曲马多对垂体后叶素致大鼠心肌缺血的影响  

The Effect of Tramadol on Rats Myocardial Ischemia for Pituitrin

作　　者：吕建英[1] 包长顺[1] 包文朝[1] 

机构地区：[1]内蒙古民族大学附属医院麻醉科,内蒙古通辽028000

出　　处：《医学信息》2013年第8期343-344,共2页Journal of Medical Information

摘　　要：目的观察曲马多对垂体后叶素所致急性0肌缺血的保护作用。方法将60只大鼠随机分成正常对照组、模型组、曲马多低、中、高荆量组和硝酸甘油组．每组10只，各组灌胃给药3d后．用垂体后叶素建立大鼠急性心肌缺血模型，观察曲马多对大鼠心电图S—T段和T的波变化及血清LDH、CK的影响。结果中、高剂量曲马多能明显抑制垂体后叶素引起的大鼠心电图S—T段的上移和T波的抬高．降低血清LDH、CK的含量，与模型组比较P〈0．01。结论曲马多有明显的抗心肌缺血的作用。Objective To observe the protective action of Tramadol on acute myocardial isehemia for pituitrin.Methods 60 rats were divided into control group,model group, high,middle and low dose of tramadol group,there were ten rats in each group.After intragastfic administration for 3 days build the rats model of acute myocardial ischemia for pituitrin and then observe the effect of tramadol on the changes of ECG S-T segment and T wave and LDH and CK in serum.Results Tramadol restrains ECG S-T segment from moving up and T wave from raising and reduce LDH and CK in serum compared with control group（P〈O.01）.Conclusion Tramadol have the obvious effect of anti-myocardial ischemia.

关 键 词：曲马多 垂体后叶素 心肌缺血 大鼠 

分 类 号：R542.2[医药卫生—心血管疾病]