γ-羟基丁烯酸内酯类化合物的光敏氧化合成方法探究  

Preparation of γ-Butenolide Derivatives via Dye-sensitized Photooxygenation

作　　者：王伟[1] 张焱[1] 李文霞[1] 桑安国[1] 贺寻[1] 

机构地区：[1]北京服装学院材料科学与工程学院,北京100029

出　　处：《北京服装学院学报（自然科学版）》2012年第4期1-5,共5页Journal of Beijing Institute of Fashion Technology：Natural Science Edition

基　　金：北京市优秀人才培养资助(2010D005001000004);国家自然科学基金委青年科学基金项目资助(51003002)

摘　　要：γ-羟基丁烯酸内酯是具有生物活性的多种药物的重要组成部分,以呋喃衍生物(糠醛等)为原料,在光敏剂玫瑰红存在下,可见光照射,发生单重态氧光敏氧化反应,制得γ-羟基丁烯酸内酯类化合物,产率可达85%,并进一步探讨了不同底物、溶剂极性、氧气流速、光敏剂浓度对光敏氧化反应的影响.5-hydroxy-2-（5H）-furanone derivatives is a key constituent of many biomedical products.In this research,the rose bengal（RB） dyes were applied in the organic synthesis as photosensitizer.Furan derivatives were used as the substrates for the photooxygenation reaction.The desired γ-butenolide and its derivatives were obtained.The yields were up to 85%.And the reaction conditions such as the substrate,polarity of the solvent,the oxygen flow rate and the concentration of sensitizer were further explored.

关 键 词：γ-羟基丁烯酸内酯 光敏剂 单重态氧 光敏氧化反应 

分 类 号：TQ245.24[化学工程—有机化工]