类风湿性关节炎相关细胞因子的研究进展  

Research on the cytokines associated with rheumatoid arthritis

作　　者：施晓柯[1] 

机构地区：[1]中山大学中山医学院,广州510080

出　　处：《中山大学研究生学刊（自然科学与医学版）》2012年第4期1-5,共5页Journal of the Graduates Sun YAT-SEN University(Natural Sciences.Medicine)

摘　　要：类风湿性关节炎(Rheumatoid Arthritis,RA)是一种以关节炎症损害和滑膜过度增生为主要特点的自身免疫性疾病,伴随有关节的肿胀和疼痛﹑全身多系统的受累。目前的研究认为,许多细胞因子在类风湿性关节炎的发病过程中起着重要作用,研究比较详细的有IL-1﹑TNF-α﹑IL-17﹑IL-6﹑MMPs和PDGF等。研究这些细胞因子在RA发病过程中的机制对于我们开发治疗RA的新方案有着重要作用,本文就当前的研究新进展开展具体阐述。Rheumatoid arthritis is an autoimmune disease characterized by the inflammatory damage of the joint and hyperplasia of synovial membrane, along with swelling and pain of the joint, multi-system involved. The current research showed that many cytokines took an important part in the development and progress of rheumatoid arthritis, such as IL-1 , TNF-α , IL-17 , PDGF and MMPs. The research to explore the function of eytokines in RA will facilitate us to develop new drugs for the patients; this paper aims to explain the current study on cytokines associated with RA.

关 键 词：类风湿性关节炎 细胞因子 药物治疗 

分 类 号：S852.4[农业科学—基础兽医学]