阿尔茨海默病的动物模型制备及药物治疗  

Animal Models of Alzheimer’s Disease and Pharmacotherapeutics

作　　者：靳淼[1] 安红梅[1] 

机构地区：[1]上海中医药大学附属龙华医院脑病科

出　　处：《神经药理学报》2011年第6期28-36,共9页Acta Neuropharmacologica

基　　金：上海市教育委员会科研(创新)项目(No.10YZ58);上海市科委中药现代化项目(No.10DZ1971200;12401904400);国家自然科学基金项目(No.81072789)

摘　　要：本文综述了近年来阿尔茨海默病(Alzheimer’s disease,AD)的动物模型制备及药物治疗的研究进展。根据AD发病机制的研究,概括了AD动物模型制备的种类,指出目前还缺乏能全面复制病因、病理改变的AD疾病模型。在AD的治疗中,总结了目前的药物治疗种类,提出针对Aβ和Tau蛋白的治疗仍是AD治疗研究热点,中医药在AD治疗中也起到了一定作用,并显示出良好的应用前景。This paper reviewed recent progress in animal models of Alzheimer’s disease （AD） and pharmacotherapy of AD. Herein, we summarized the different types of AD animal models based on the pathogenesis of AD, and concluded that there is a lack of full demonstration of the etiology and pathological changes of AD disease in animal models. We also summarized the current available medication treatments of AD. Aβand Tau protein are still the research focus in the field of AD treatment. Traditional Chinese Medicine also plays a certain role in the treatment of AD, and shows a good prospect.

关 键 词：阿尔茨海默病 动物模型 药物治疗 中医药 

分 类 号：R965.1[医药卫生—药理学]