缓激肽B2受体基因多态性对骨关节炎易感性和严重性的影响  

Bradykinin B2 Receptor Polymorphisms Contribute to the Susceptibility and Severity of Osteoarthritis

作　　者：陈烁[1] 刘宏滨[1] 王和洪[1] 赵日光[1] 蔡筱松 韩冰[1] 李军[2] 

机构地区：[1]解放军第97医院骨科,江苏徐州221004 [2]第四军医大学附属唐都医院骨科,陕西西安710038

出　　处：《现代生物医学进展》2013年第12期2328-2331,共4页Progress in Modern Biomedicine

摘　　要：目的:研究缓激肽B2受体(BDKRB2)基因多态性对骨关节炎的易感性和严重性的影响。方法:在325名原发性膝关节骨关节炎患者及318名健康志愿者中,针对缓激肽B2受体基因多态性-58T/C和+9/-9bp,分别进行基因型测定。结果:+9/-9bp基因多态性的基因型分布和等位基因频率,在骨关节炎组与对照组之间存在明显差异。回归分析显示-9/-9基因型相对于+9/+9基因型,罹患膝关节骨关节炎的风险明显增高(OR=2.354,P<0.001)。同时,+9/-9bp基因多态性与骨关节炎的放射学分型存在相关性,-9bp等位基因可能与骨关节炎的严重程度有关。-58T/C基因多态性与骨关节炎的易感性和严重性无相关性。结论:缓激肽B2受体基因多态性+9/-9bp可能成为检测骨关节炎易感性和严重性的基因标记物。Objective： To study the effect of Bradykinin B2 Receptor Polymorphisms on the susceptibility and severity of Osteoarthritis. Methods： A total of 325 patients with primary knee OA and 318 healthy volunteer were recruited. BDKRB2 gene polymorphisms, -58T/C and ＋9/-9 bp polymorphisms, were genotyped. Results： The genotype distributions and allele frequencies of ＋9/-9 bp polymorphisms significantly differed between OA and control subjects. Logistic regression analysis showed carriers with -9/-9 genotype had a significantly increased risk for knee OA compared with the ＋9/＋9 genotype （OR = 2.354, P〈 0.001）. The ＋9/-9 bp polymorphisms also determined the OA radiographic severity. The presence of-9 bp was associated with severer OA. The -58T/C polym- orphisms did not affect OA risk and severity. Conclusion： The ＋9/-9 bp polymorphisms of BDKRB2 gene may be used as a genetic marker for the susceptibility and severity of OA.

关 键 词：缓激肽B2受体 基因多态性 骨关节炎 

分 类 号：R684.3[医药卫生—骨科学]