胺碘酮及阿托伐他汀联合应用对阵发性心房颤动复律后维持窦性心律的治疗分析  

Treatment Analysis on Amiodarone and Atorvastatin Combined Application in Paroxysmal Atrial Fibrillation after Cardioerter Maintenance of Sinus Rhythm

作　　者：杨玲[1] 孙炜[1] 梁泽明[1] 马为[2] 

机构地区：[1]宝鸡市中医医院心血管内科,陕西宝鸡721001 [2]北京大学第一医院心内科,北京100000

出　　处：《现代生物医学进展》2013年第12期2338-2341,共4页Progress in Modern Biomedicine

摘　　要：目的:分析胺碘酮和阿托伐他汀联合使用对阵发性房颤复律后维持窦性心律的疗效。方法:入选阵发性房颤患者80例,经成功转复心律治疗后按随机原则分成治疗组及对照组各40例,治疗组口服胺碘酮,对照组联合使用胺碘酮和阿托伐他汀,治疗18个月后对比两组窦性心律的维持率。结果:经治疗,联合用药组12个月时窦性心律的维持率显著高于对照组(82.5%vs.62.5%,P<0.05),18个月时窦性心律的维持率也显著高于对照组(80.0%vs.55.0%,P<0.05)。结论:胺碘酮和阿托伐他汀联合使用对阵发性AF复律后维持窦性心律疗效显著,优于胺碘酮单药治疗,值得临床推广。Objective： To analyze the curative effect of amiodarone and atorvastatin combined application in paroxysmal atrial fibrillation after cardioerter maintenance of sinus rhythm. Methods： 80 cases with idiopathic in atrial fibrillation were chosen, the successful converting rhythm of the heart after treatment according to the principle of random divided into treatment group and control group, the treatment group used oral amiodaxone, and control group used combined of amiodarone and atorvastatin. 18 months after treatment, sinus rhythm maintenance ratio in the two groups were compared. Results： After treatment, in the combined treatment group for 12 months, sinus rhythm maintenance rate was significantly higher than those in the control group （82.5% vs 62.5%, P〈0.05）, and sinus rhythm maintenance ratio in the combined treatment group for 18 months was also significantly higher than those in the control group （80.0% vs 55.0%, P〈0.05）. Conclusion： Amiodarone combined with atorvastatin have obvious efficacy for paroxysmal AF cardioerter maintenance of sinus rhythm, is better than that of amiodarone monotherapy, it is worth of clinical promotion.

关 键 词：胺碘酮 阿托伐他汀 窦性心律 维持率 阵发性心房颤动 

分 类 号：R541.75[医药卫生—心血管疾病]