胸腔局部顺铂联合热灌注治疗恶性胸腔积液疗效观察  

The effect of Intrapleural Hyperthermic Perfusion Combined with Cisplatin in the treatment of Malignant Pleural Effusion

作　　者：郭黔[1] 陈非[1] 罗舒[1] 李旭敏[1] 夏徽[1] 王超[1] 

机构地区：[1]遂宁市第一人民医院肿瘤科,四川遂宁629000

出　　处：《西部医学》2013年第2期246-248,共3页Medical Journal of West China

摘　　要：目的探讨胸腔局部顺铂联合热灌注治疗恶性胸腔积液的临床疗效。方法将出现恶性胸腔积液的非小细胞肺癌患者76例随机均分为顺铂治疗组和热灌注+顺铂治疗组,两组患者均给予顺铂局部治疗,热灌注+顺铂治疗组患者在顺铂局部治疗的基础上给予胸腔热灌注辅助治疗。治疗两个疗程后,对两组患者进行临床疗效评定和生存质量评分测定。结果在通过两个疗程的治疗后,临床疗效观察显示,顺铂治疗组有效率为42.1%;热灌注+顺铂治疗组有效率为78.9%。两组间临床疗效的差异有统计学意义(χ2=17.113,P=0.001)。生活质量评分显示,顺铂治疗组改善率为34.2%,热灌注+顺铂治疗组改善率为63.2%,两组间有效率差异有统计学意义(χ2=10.868,P=0.004)。结论胸腔热灌注辅助治疗恶性胸腔积液安全有效,可在临床推广应用。Objective To investigate the effect of intrapleural hyperthermic perfusion （CIHP） on the management of malignant pleural effusion （MPE）. Methods Seventy six patients with non-small cell lung cancer （NSCLC） induced malignant pleural effusion （MPE） were randomly separated into 2 groups （n=38）, eisplatin group and CIHP; cisplatin group. After 2 courses of treatment, response rates and KPS scores were observed. Results After 2 courses of treatment, response rates and KPS scores in CIHP＋ cisplatin group were better than in cisplatin group. No severe side effect was found in the CIHP treatment. Conclusion Intrapleural hyperthermic perfusion （CIHP） is a safety and effective treatmerit on malignant pleural effusion.

关 键 词：热灌注 恶性胸腔积液 顺铂 

分 类 号：R561.3[医药卫生—呼吸系统]