海南普通人群中基因Ⅳ型HEV的血清流行病学调查  

Seroepidemiological survey on the infection of genotype Ⅳ hepatitis E virus among population in Hainan

作　　者：杜丽[1] 雷明[1] 刘涛[1] 成鹰[1] 符生苗[2] 王凤阳[1] 

机构地区：[1]海南大学农学院,海南省热带动物繁育与疫病研究重点实验室,海口市动物基因工程重点实验室,海南海口570228 [2]海南省人民医院医学检验部,海南海口570311

出　　处：《中国热带医学》2013年第3期363-364,共2页China Tropical Medicine

基　　金：国家自然科学基金项目(No.30660139);海南省社发专项(No.2012SF016);海口市重点科技项目(No.2010-048)

摘　　要：目的了解基因Ⅳ型戊型肝炎病毒在海南普通人群中的感染情况,为海南防治戊型肝炎工作提供依据。方法收集海南普通人群各年龄组血清标本235份,以Ⅳ型HEV ORF3蛋白的原核表达产物为抗原,应用ELISA法检测抗-HEV IgG抗体。结果抗-HEV阳性率为3.0%,男、女性抗-HEV阳性率分别为2.7%和3.4%,差异无统计学意义(P>0.05);青壮年、中年、老年抗-HEV阳性率分别为2.0%、3.0%和3.5%,差异无统计学意(P>0.05)。结论在海南普通人群中,基因Ⅳ型戊型肝炎病毒感染多以散发形式存在。Objective To understand the sero-prevalence of genotype Ⅳ hepatitis E virus（HEV）infection among populations in Hainan and provide important information for the prevention and control of HE.Methods A total of 235 serum samples from the general population were collected random from each age group in 2008,Anti-HEV IgG was detected by ELISA assay established in our lab.Results The infection rates of anti-HEV was 3.0%,in males and females it was 2.7% and 3.4% respectively,and there was no significant different between males and females（P0.05）;Anti-HEV positive rates were 2.0%,3.0% and 3.5% in adults,middle-aged and the older,respectively,there was also no significant difference between them（P0.05）.Conclusions The prevalence of genotype Ⅳ hepatitis E virus（HEV）infection majorly exist in sporadic forms in Hainan,and the infective rate was lower than that of the national average level.

关 键 词：基因Ⅳ型 戊型肝炎病毒 抗-HEV抗体 流行病学 

分 类 号：R512.6[医药卫生—内科学]