冻融胚胎卵裂球损伤对胚胎发育潜能的影响  

Effect of blastoomere injury of frozen-thawed embryo on developmental potential of embryo

作　　者：孟江萍[1] 幸贵邦[1] 

机构地区：[1]重庆医科大学附属第一医院辅助生殖中心,重庆400016

出　　处：《中国妇幼保健》2013年第15期2427-2428,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨冻融胚胎卵裂球完整性对胚胎发育潜能的影响。方法:回顾性分析126个冻融胚胎移植周期,按照移植胚胎的卵裂球的完整性分为两组:无损伤组(所有移植胚胎均完整无损,n=78),部分损伤组(移植胚胎中至少含1个有卵裂球损伤的胚胎,n=48),比较两组临床妊娠率、种植率和流产率。结果:无损伤组临床妊娠率为37.18%(29/78),种植率23.72%(37/156),流产率3.45%(1/29)。部分损伤组临床妊娠率为33.33%(16/48),种植率13.85%(18/130),流产率12.50%(2/16),两组临床妊娠率和流产率比较,差异无统计学意义(P>0.05),种植率比较差异具有统计学意义(P<0.05)。结论:部分卵裂球损伤的冻融胚胎,其种植潜能降低,卵裂球完整性是影响临床结局的关键性因素。Objective： To explore the effect of blastomere integrity of frozen - thawed embryo on developmental potential of embry- o. Methods： A total of 126 frozen - thawed embryo thansfer cycles were analyzed retrospectively, then they were divided into two groups ac- cording to blastomere integrity： no - injury group （ all the embryos were intact, n = 78） and partial injury group （ including at least one dam- aged embryo among all the embryos, n = 48 ） ; the clinical pregnancy rates, implantation rates, and abortion rates in the two groups were compared. Results： The clinical pregnancy rate, implantation rate, and abortion rate in no - injury group were 37. 18% （29/78）, 23.72% （37/156）, and 3.45% （1/29）, respectively; the clinical pregnancy rate, implantation rate, and abortion rate in partial injury group were 33.33% （16/48）, 13.85% （18/130）, and 12. 50% （2/16）, respectively. There was no statistically significant difference in clinical pregnancy rate and abortion rate between the two groups （ P 〉 0. 05）, but there was statistically significant difference in implantation rate be- tween the two groups （P 〈 0. 05 ） . Conclusion： The implantation potential of partial frozen - thawed embryos with blastomere injury de- creases, integrity of blastomere is one of key factors affecting clinical outcome.

关 键 词：卵裂球完整性 胚胎冷冻 临床妊娠率 着床率 

分 类 号：R321[医药卫生—人体解剖和组织胚胎学]