延安市中老年健康体检人群血脂、叶酸和同型半胱氨酸水平调查  

Study on Level of Lipid,Folate and Homocysteine in Middle-Aged and the Elderly Population in Yan＇an

作　　者：祁宏英[1] 李华 周宏莉[1] 魏红梅[1] 

机构地区：[1]陕西省延安市人民医院输血科,陕西延安716000 [2]府谷县人民医院,陕西榆林719400

出　　处：《现代检验医学杂志》2013年第2期135-138,共4页Journal of Modern Laboratory Medicine

摘　　要：目的了解延安市中老年人群血脂、叶酸和同型半胱氨酸水平。方法采集2009年5月～2012年9月延安市人民医院1364例健康体检者血清，测定总胆固醇（TC）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）、叶酸和同型半胱氨酸水平并进行统计学分析。结果女性血清TC水平随年龄增加而升高（t=7．542，5．649，P值均〈0．05），中年组女性血清TC水平低于男性（t=4．536，P〈0．05），而老年前期组和老年组女性血清TC水平高于男性（t=3．526，6．423，P值均〈0．05）。中年组女性血清LDL-C水平低于男性而老年前期组和老年组女性血清TC水平高于男性（t=4．732，6．583，5．013，P值均〈0．05），与TC水平变化类似。各组女性HDL—C均高于男性（t=5．837，5．678，4．928，P值均〈0．05）。中年组女性血清TG水平高于男性（t=6．231，P〈0．05），老年前期组女性血清TG水平低于男性（t=4．861，P〈0．05）。男性叶酸水平低于女性（t=5．674，8．325，6．437，P值均〈0．05），而血清叶酸水平在不同年龄组之间差异均无统计学显著性意义。各年龄组中男性血浆同型半胱氨酸水平与女性相比均升高（t=9．635，10．139，9．263，P值均〈0．05）；高同型半胱氨酸血症在普通人群的总发生率为21．5％，男性为29．2％，高于女性（χ^2=30．45，P〈0．05）。结论延安市中老年人群血脂及同型半胱氨酸水平在性别及各年龄组之间有差异，叶酸在性别之间有差异。Objective To investigate the levels of lipid,folate and homocysteine in the middle-aged and the elderly population in Yan＇an city. Methods The levels of total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, low-d4ensity lipoprotein cholesterol （LDL-C）,triglycerides （TG）, folate and homoeysteine in 1 364 cases of healthy subjects at Yan＇an People＇s Hospital from May 2009 to September 2012 were determined and statistically analyzed. Results The female serum TC level increased with age （t= 7. 542,5. 649, P〈0.05）, serum TC level of middle-aged group of famale was less than of male （t= 4. 536, P〈0. 05）, serum TC level of pre-elderly and elderly groups of famale were than of male （t= 3.526,6. 423, P〈0.05）. Serum TC level of middle-aged group of famale was less than of male and the level of pre-elderly and elderly groups of famale were than of male （t=4. 732,6. 583,5. 013,P〈0.05） ,which changes similar to the TC. The group of famale HDL-C were higher than of male （t= 5. 837,5. 678,4. 928, P〈0.05）. The middle-aged group of famale serum TG levels was higher than of male （t = 6.231, P〈0. 05）, and the pre-elderly group of famale serum TG levels was less than of male （t= 4. 861, P〈.05）. Serum folate levels in male were significantly lower than that of female （t= 5. 674,8. 325,6. 437, P〈0.05） ,and there was no significant difference between different age groups. Male plasma homocysteine levels was significantly higher than that of female in each age group （t= 9. 635,10. 139,9. 263, P〈0.05）. The total incidence rate of high hyperhomocysteinemia in the general population was 21.5 %. Significant difference in the incidence of male and female group was observed, with a incidence of 29.2 % for male significantly higher than female （χ^2 = 30.45, P〈0.05）. Conclusion In the middle-aged and the elderly population in Yan＇an,there were evidently difference of lipid and homocysteine in different age and sex group,but signifieanlt differen

关 键 词：同型半胱氨酸 叶酸 血脂 中老年 延安市 

分 类 号：R446.112[医药卫生—诊断学]