清下消补4法联用治疗肝硬化高水平透明质酸血症40例临床观察  

Treatment of 40 Cases of Hyperhyaluronemia due to Liver Cirrhosis by Combination of Drugs for Heat - reducing. Purgation, Resolving and Tonification

作　　者：杨宏志[1] 杨耀武[2] 沈伟生[2] 陈琰碧[1] 王拥泽 关卫兵[1] 边壮[1] 

机构地区：[1]中山医科大学附属第三医院中医科,广东省广州市石牌510630 [2]江苏省江阴市第二人民医院

出　　处：《中医杂志》2000年第9期543-544,共2页Journal of Traditional Chinese Medicine

基　　金：广东省科委1997年重点攻关项目(97030);广东省中医药管理局1997年立项课题(97222)

摘　　要：观察中医清、下、消、补4法联用治疗肝硬化高水平透明质酸血症的疗效。方法:选择40例乙肝肝硬化透明质酸(HA)>800ng/ml同时伴有一氧化氮(NO)增高的肝硬化患者,观察经中药治疗半年与2年的指标变化。结果:该治疗方法可明显消除病人症状、体征,使多数患者两氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、球蛋白、白蛋白、胆红素复常,血清透明质酸、NO降至正常水平。腹B超检测门静脉,40％宽度缩小,50％维持不变;脾厚50％缩小,40％不变。结论:4法联用治疗肝硬化高水平透明质酸具有良好疗效,其作用可能与下法用大黄排毒利胆通腑,下瘀热作用有关,其机理有待进一步研究。Patients of liver cirrhosis with high blood hyaluronic acid level (>800 ng/L) and elevated NO content were enrolled to study the efficacy of treatment with a combination of drugs for heat - reducing, purgation, resolving and tonification for 6 months to 2 years. The symptoms and signs were markedly ameliorated: the level of GPT, GOT, globulin, albumin and bilirubin contents restored to normal level. In B -ultrasonographic examination, a decrease the width of the portal vein and the spleen was found in 50% of the patients. The authors concluded that the combined use of drugs for heat - reducing, purgation, resolving and tonification was effective in treating hyperhyaluronemia due to liver cirrhosis. The ingredient rhemannia root may play the key role in its actions of expelling toxic materials, normalizing the functions of the viscera and discharge of bile, and removing the stagnated heat.

关 键 词：肝硬化 中医药疗法 透明质酸血症 清下消补 

分 类 号：R259.7[医药卫生—中西医结合]