^99Tc-MIBI门控心肌灌注显像评价缺血性心肌病患者干细胞移植效果的临床研究  

The study of ^99Fc^m-MIBI gated myocardial perfusion imaging for evaluation of the mesenchymal stem cell transplantation in patients with ischemic myocardium

作　　者：郝骥[1] 祁春梅[1] 武维恒[1] 蔡文标[1] 李莉[1] 冯建启[1] 刁军[1] 吴浩[1] 

机构地区：[1]徐州矿务集团总医院徐州医学院第二附属医院心内科,江苏省221002

出　　处：《中国心血管病研究》2013年第5期345-348,I0002,共5页Chinese Journal of Cardiovascular Research

摘　　要：目的用^99Tc^m-甲氧基异丁基异腈（MIBI）门控心肌灌注显像方法评价缺血性心肌病患者自体骨髓干细胞（MSC）移植术的疗效。方法缺血性心肌病患者42例，其中20例为试验组，行常规药物治疗联合自体MSC移植术；拒行自体MSC移植术治疗22例患者作为对照组，行常规药物治疗。治疗后3个月和6个月时进行^99Tc^m—MIBI门控心肌灌注断层显像，通过心肌血流灌注改善程度评价自体MSC移植术疗效。结果患者3个月和6个月时心肌放射性缺损节段数目试验组为2．66＋0．94和2．52±0．82，较对照组的5．64±1．56和5．51±1．45明显减少（￡=2．43，2．65，P均〈0．05）。与自体MSC移植术治疗前（5．72±1．54）相比，试验组患者3个月和6个月时心肌放射性缺损节段数目（2．66±0．94，2．52±0．82）均明显减少（t=2．37，2．58，P均〈0．05）。与自体MSC移植术治疗前160m相比，试验组患者3个月和6个月时6min步行试验距离（368rn和466m）均明显增加（t=2．55，2．48，P均〈0．05）。结论^99TC^m-MIBI门控心肌灌注显像可评价缺血性心肌病患者自体MSC移植的疗效。Objective The objective of this study was to evaluate the clinical value of ^99Fc^m-methoxy- isobutylisonitrile （MIBI） gated myocardial perfusion imaging in patients with ischemic myocardium treated by mes- enchymal stem cell （MSC） transplantation. Methods Forty-two patients with ischemic myocardium who have ac- cepted standard medication were included. 20 of them underwent MSC transplantation therapy. All the patients were examined by ^99Fc^m-MIBI gated myocardial perfusion imaging at baseline and after therapy to evaluate the left ven- tricular myocardial perfusion. The t-test was used to compare data statistically with SPSS 13.0. Results After 3, 6 months, the number of myocardial segments with perfusion defects decreased in the patients treated by MSC transplantation （2.66±0.94） and （2.52±0.82）, compared with the control group without MSC transplantation thera- py （5.64±1.56 ） and （5.51 ±1.45 ） （t =2.43, 2.65, both P〈0.05 ）. In the patients treated by MSC transplantation the number of myocardial segments with perfusion defects （5.72＋1.54） decreased after MSC transplantation （2.66± 0.94） and （2.52±0.82）（t=2.37, 2.58, both P〈0.05）. In the patients treated by MSC transplantation the distance （160 m） increased after MSC transplantation （368 m and 466 m, t=2.55, 2.48, both P〈0.05）. Conclusion ^99Fc^m-MIBI gated myocardial perfusion imaging is an effective method to evaluate the value of MSC transplantationin patients with ischemic myocardium.

关 键 词：缺血性心肌病 干细胞治疗 心肌灌注显像 

分 类 号：R542.2[医药卫生—心血管疾病]