2型糖尿病视网膜病变与血清脂蛋白(a)的关系  

The Relationship of Type-2 Diabetes Mellitus Complicated by Diabetic Retinopathy with the Changes of Serum Lp(a) Levels

作　　者：魏进[1] 高明殿[1] 孙正凯[1] 

机构地区：[1]山东省昌邑市人民医院内分泌科,山东昌邑261300

出　　处：《中国医药指南》2013年第8期438-439,共2页Guide of China Medicine

摘　　要：目的探讨2型糖尿病视网膜病变与血清脂蛋白(a)的关系及其临床意义。方法检测了40例2型糖尿病患者的视网膜情况。按DR分期标准将该40例患者分为糖尿病正常眼底、糖尿病视网膜病变组(糖尿病DR组)各20例,并设正常对照组20例。测定了三组人群的血清Lp(a)水平,同时测定了三组人群的TC、LDL-c、HDL-c和TG水平,分析了其与血清Lp(a)的相关性。结果糖尿病正常眼底组apoB、TG、TC、LDL、Lp(a)水平较健康对照组升高,HDL-C降低,有显著性差异(P<0.05);糖尿病DR组apoB、TC、LDL、Lp(a)较NIDDM组正常眼底组明显升高,HDL-C、ApoA1降低,有显著性差异(P<0.05),TG水平无显著性差异。扣除其他因素影响,Lp(a)与TC(r=0.773,P<0.05)、LDL(r=0.784,P<0.05)均呈正相关,Lp(a)与ApoAI、ApoB、TG、LDL-C无相关性。结论 Lp(a)水平在糖尿病DR组明显升高糖尿病正常眼底组,提示Lp(a)水平可能是2型糖尿病视网膜病变发生和加重的重要因素。Objective To investigate the changes of serum Lp（a） levels of patients with type-2 diabetes mellitus complicated by diabetic retinopathy and its clinical significance. Method We tested serum Lp（a） levels of normal control subjects, Type-2 diabetics and those accompanied with diabetic retinopathy complications. Meanwhile, the levels of TG, TC, LDL-C, and HDL-C for the three groups were measured and the relationship of Lp（a） to the disease were analyged. ResuLts It was found that the Lp（a）, TC and LDL-C in one group patients （diabetes mellitus complicated by diabetic retinopathy） were significantly higher than that in the other two groups （P〈0.05）; and there is no similar changes of serum TG （P〉0.05）. Conclusion The serum Lp（a） levels are increased in Type-2 diabetes and more obviously higher in diabetes with diabetic retinopathy, showing certain clinical and practical value.

关 键 词：2型糖尿病 糖尿病视网膜病变 血脂 脂蛋白(a) 

分 类 号：R587.1[医药卫生—内分泌]