外科手术与低磷血症相互关系的实验研究  

EXPERIMENTAL STUDY ON SURGICAL OPERATION AND HYPOPHOSPHATEMIA

作　　者：朱捷[1] 张群华[2] 陈丽莉[2] 

机构地区：[1]华东医院普外科,上海200040 [2]上海医科大学附属华山医院外科教研室,上海200040

出　　处：《中国普外基础与临床杂志》2000年第5期282-284,共3页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的　通过研究大鼠腹部手术前后血磷等指标的变化 ,探讨手术与低磷血症的关系、低磷对机体的影响以及补磷治疗的效果。方法　雄性SD大鼠 6 4只 ,分成 2组 ,一组饮用配制液造成体内磷缺乏 ,另组饮清水作为对照。 3周后行胆总管结扎术 ,观察血磷及其它生化指标的变化。然后每组再分为补磷组及不补磷组 ,观察 4组大鼠生化指标、生存率及重要器官电镜结构的变化。结果　手术后各组大鼠均有不同程度的血磷下降 ;术前磷缺乏组血磷及平均动脉压的下降尤为明显 ;该组大鼠补充磷后 ,5天生存率有较明显的改善 ,且电镜下脏器的损害较轻微。结论　腹部手术后可引起血磷浓度的降低 ,术前存在磷缺乏者术后可发生严重的低磷血症 ;严重的低磷血症加重了手术创伤对机体的损害 ;HT6”,5”] [WT5”BZ] [WT5”HZ]Objective [WT5”BZ]To investigate the relationship between surgical operation and hypophosphatemia, to observe the possible damage of hypophosphatemia and to assess the value of postoperative phosphate supplementation. [WT5”HZ]Methods [WT5”BZ]Sixty four male SD rats were randomly divided into 2 groups, Group Ⅰ, drinking a specially prepared solution to reduce their phosphate storage, Group Ⅱ, drinking water as a control. All received common bile duct ligation 3 weeks later. The serum biochemical data including phosphate level were obtained before and after operation. Then half of rats in each group were supplied with NaH 2PO 4 5 day survival rates were analyzed with statistic methods and their vital organs were observed under electron microscope. [WT5”HZ]Results [WT5”BZ]The phosphate level of each group was descended after operation. The group with phosphate shortage before operation (group Ⅰ) had a greatest fall of phosphate and average arterial pressure. The phosphate supplied rats had a minor change of vital organs under electron microscope scan and higher 5 day survival rate compared to others in this group. [WT5”HZ]Conclusion [WT5”BZ]Abdominal surgery may induce postoperative hypophosphatemia, especially when the phosphate has been lacking before operation. Severe hypophosphatemia, superimposed on surgical trauma, enhances the damage to the body. Prompt supplement of phosphate will improve the prognosis of surgical operation. [HT6,5”] [WT5”HZ]

关 键 词：腹部外科手术 低磷血症 动物模型 

分 类 号：R619[医药卫生—外科学]