络石藤地上部分中的一个新异黄酮苷(英文)  

A new isoflavonoid glycoside from the aerial parts of Trachelospermum jasminoides

作　　者：张健[1,2] 殷志琦[1] 梁敬钰[1] 

机构地区：[1]中国药科大学天然药物化学教研室,南京210009 [2]江苏省中医药研究院转化医学实验室,南京210028

出　　处：《中国天然药物》2013年第3期274-276,共3页

基　　金：supported by the Natural Science Foundation of Jiangsu Province(No.BK2010594)~~

摘　　要：目的:对络石藤地上部分化学成分进行研究。方法:运用多种色谱方法分离化合物,并采用现代光谱技术鉴定化合物的结构。此外,测定了化合物1对HepG2和HL-60的细胞毒活性。结果:从络石藤地上部分分离得到5个苷类化合物:3',7-二甲氧基异黄酮-4',5-二-O-β-D-吡喃葡萄糖苷(1),络石苷(2),去甲络石苷元5'-C-β-D-葡萄糖苷(3),木犀草素-4'-O-β-D-芸香糖苷(4),木犀草素-7-O-β-D-吡喃葡萄糖苷(5)。结论:化合物1为新化合物,对HepG2和HL-60的细胞毒活性显示其IC50为131.5和58.2μmol·L1。AIM： To study the chemical constituents from the aerial parts of Trachelospermum jasminoides. METHODS： Com- pounds were isolated by various chromatographic methods and their structures were elucidated on the basis of spectral techniques. In addition, the inhibitory activity against HepG2 and HL-60 of compound 1 was evaluated. RESULTS： Five compounds were isolated and identified as 3＇, 7-dimethoxyisoflavanone-4＇, 5-di-O-fl-D-glucopyranoside （1）, tracheloside （2）, nortrachelogenin 5＇-C-fl-glucopyranoside （3）, luteolin-4＇-O-fl-D-rutinoside （4）, and luteolin-7-O-fl-D-glucopyranoside （5）. CONCLUSION： Compound 1 is a new isoflavonoid glycoside. It showed weak inhibitory activity against HepG2 and HL-60 cancer cells with IC50 values of 131.5 and 58.2 gmol.L-1, respectively.

关 键 词：络石藤 异黄酮苷 木脂素苷 细胞毒 

分 类 号：R284.1[医药卫生—中药学]