NGAL在急性肾损伤早期临床诊断中的作用  

Role of NGAL in early clinical diagnosis of acute kidney injury

作　　者：徐兴凯[1] 李岩(综述)[2] 林兆奋[3] 张连东(审校)[1] 

机构地区：[1]上海中医药大学附属曙光医院宝山分院急诊科,上海201900 [2]上海交通大学附属上海市第一人民医院危重病急救科,上海200080 [3]解放军第二军医大学附属长征医院急救科,上海200003

出　　处：《中国急救医学》2013年第5期474-478,共5页Chinese Journal of Critical Care Medicine

摘　　要：血肌酐和尿量是急性肾损伤（AKI）诊断的检测指标，也是目前AKI分级的依据。但两者均会受到多种因素影响，且不能早期及时反映肾脏功能。流行病学调查显示，由于AKI缺乏特异性的早期临床诊断指标，易导致其诊治的延误，从而使AKI的发病率、病死率居高不下。中性粒细胞明胶酶相关脂质运载蛋白（NGAL）是脂质运载蛋白家族的新成员，研究表明，其是一种新型的AKI临床诊断的标志物，正越来越受到关注。本文现就NGAL在AKI早期临床诊断中的作用研究近况作一综述。Serum creatinine and urine volume are detection index in diagnosing acute renal injure（ AKI）, and are also currently the AKI grading reference. However, both of them can be affected by many factors, and can not early reflect kidney function timely. Epidemiology investigation shows that the diagnosis and treatment of AKI will easily be delayed due to the lack of specific and early clinical diagnosis index of AKI. Thus the AKI morbidity, mortality rates remain high. Nentrophil gelatinase - associated lipocalin（NGAL） is a new member of the lipocalin super - family. Research shows that NGAL is a new clinical diagnostic marker of AKI, and it is paid more and more attention. The recent research on the function of NGAL in AKI early clinical diagnosis is reviewed in this paper.

关 键 词：急性肾损伤(AKI) 中性粒细胞明胶酶相关脂质运载蛋白(NGAL) 新型生物学标志物 血肌酐 尿量 肾小球滤过率 

分 类 号：R587.2[医药卫生—内分泌]